Myeloperoxidase: friend and foe

By S. Klebanoff. Journal of Leukocyte Biology, 2005

2,257 citations recorded by the source corpus.

Subfields: Immunology, Inorganic Chemistry, Physiology

View Paper: https://www.semanticscholar.org/paper/aaa6f576d13183880fc517353219f0a5a9d8e927

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. C. Winterbourn
2. C. Nathan
3. S. Klebanoff
4. W. Nauseef
5. J. Lambeth
6. M. Hampton
7. A. Kettle
8. M. Levi

In Inorganic Chemistry

1. C. Winterbourn
2. W. Nauseef
3. C. Nathan
4. J. Lambeth
5. A. Kettle

In Physiology

1. C. Winterbourn
2. C. Nathan
3. W. Nauseef
4. S. Klebanoff
5. J. Lambeth
6. M. Hampton
7. A. Kettle
8. Rafael Radi

Citations in the corpus

• Myeloperoxidase: a front‐line defender against phagocytosed microorganisms (2013, background): “bination with H2O2 and chloride, constitutes a potent antimicrobial system [2].”
• Reactive Oxygen Species and Neutrophil Function. (2016, background): “Although defective killing cannot account for all of the problems associated with CGD, isolated neutrophils that lack NOX2 activity kill a wide range of microorganisms poorly, and this is a major contributor to the disease (56).”
• The role of ADAMTS13 in acute myocardial infarction: cause or consequence? (2016, methodology): “To assess inflammatory involvement, myocardial tissue was stained for MPO and CD45.”
• Health effects of quercetin: from antioxidant to nutraceutical. (2008, background): “Furthermore, the bactericidal activities of the phagocytes are boosted by the formation of the highly reactive HOCl out of H2O2 and chloride, a reaction catalyzed by the enzyme myeloperoxidase (Hampton et al., 1998; Klebanoff, 2005).”
• Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. (2007, background): “In addition, myeloperoxidase (MPO) is secreted into the phagosome where it converts H2O2 (produced by Nox2) plus chloride into HOCl; the latter has a direct microbicidal effect [4,5] (although surprisingly, MPO-deficient individuals do not suffer from markedly increased rates or apparent severity of”
• Oxidative Stress and Antioxidant Defense (2012, background): “HOCl is highly oxidative and plays an important role in killing of the pathogens in the airways.(28) However, HOCl can also react with DNA and induce DNA–protein interactions and produce pyrimidine oxidation products and add chloride to DNA bases.”
• How human neutrophils kill and degrade microbes: an integrated view (2007, background): “The intrinsic reactivity of MPO to oxidize chloride at physiological pH to generate HOCl and the potent antimicrobial action of HOCl are well accepted (130).”
• Neutrophils and immunity: challenges and opportunities (2006, background): “Respiratory burst products and their derivatives include superoxide, singlet oxygen, ozone, hydrogen peroxide (H 2 O 2 ), hypohalous acids, chloramines and hydroxyl radical”
• Reconciling the chemistry and biology of reactive oxygen species. (2008, background): “ROS that are particularly relevant in inflammation are the unique myeloperoxidase and eosinophil peroxidase products—hypochlorous, hypobromous and hypothiocyanous acid”