Vascular NAD(P)H oxidases: specific features, expression, and regulation.

By B. Lassègue, R. Clempus. American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2003

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The role of oxidative stress in diabetic complications (2007, background): “tified in vascular smooth muscle cells (35,36),”
Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. (2007, background): “Nox2 and Nox4 are both expressed in endothelium [41,42] where under some conditions they participate in cell proliferation [43] while Nox1, Nox4 [42,44] and Nox2 [45] are expressed in vascular smooth muscle cells.”
Hydrogen Peroxide: A Signaling Messenger (2006, neutral): “In general, in mammalian cells, ROS production is greater in proliferating subconfluent cultures compared with confluent cells (23, 75, 158).”
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? (2004, background): “Upregulation of O2 - generating NAD(P)H oxidases may play a key role in causing impaired vascular tone and hypertension (Harrison et al., 2003; Lassegue & Clempus, 2003; Murphey et al., 2003).”
Redox signaling in hypertension. (2006, background): “Activation of NAD(P)H oxidase is regulated by many vasoactive hormones, growth factors (platelet-derived growth factor, transforming growth factorh) and mechanical stimuli (shear stress and stretch) [28].”
Crosstalk between mitochondria and NADPH oxidases (2011, background): “The Nox proteins vary in terms of their mode of activation and localization [87].”