Hydrogen peroxide as second messenger in lymphocyte activation

By M. Reth. Nature Immunology, 2002

820 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/a930c9c30094f92af042597e96dc0bded7fafb8a

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Citations in the corpus

Membrane transport of hydrogen peroxide. (2006, background): “The half-life of H2O2 in lymphocytes is 1 ms while that of superoxide (O) is 1 μs [5].”
Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? (2004, background): “Sources of O2 in and around the vessel wall include the vascular endothelium (especially in atherosclerotic lesions), fibroblasts, lymphocytes, phagocytes and the enzyme xanthine oxidase (Darley-Usmar & Halliwell, 1996; Reth, 2002; Rey & Pagano, 2002).”
Nitric oxide and superoxide in inflammation and immune regulation. (2003, background): “Hydrogen peroxide may inhibit protein tyrosine phosphatases, and therefore act as a secondary messenger in the initiation and amplification of signaling at the antigen receptor (81).”
Novel cell death program leads to neutrophil extracellular traps (2007, neutral): “Our data show that ROS function as signaling molecules (Reth, 2002; Rhee et al., 2005; Torres et al., 2005), but the nature of the downstream signaling is still unclear.”
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives (2020, background): “At low levels, ROS can serve as secondary messengers to activate different cellular responses [147].”
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS) (2011, background): “ROS can potentiate MAPK activation by inactivation of MAPK phosphatases through oxidation of their catalytic cysteine residues (Meng et al., 2002; Reth, 2002; Kamata et al., 2005).”
Role of Glutathione in Cancer: From Mechanisms to Therapies (2020, background): “1 us) [1,2], and can traverse membranes, making it capable of functioning as a signaling molecule.”
Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. (2007, background): “Although all these sources contribute to the overall ROS production, the vast majority of cellular ROS can be traced back to the mitochondria [1–4].”
Reactive oxygen species in vascular biology: implications in hypertension (2004, neutral): “However, there is now convincing evidence that ROS are not only toxic consequences of cellular metabolism but also essential participants in cell signaling and regulation (Griendling et al. 2000a; Sauer et al. 2001; Reth 2002; Chiarugi and Cirri 2003).”
Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways? (2011, background): “H2O2, with a relatively long half-life, good membrane permeability, and higher intracellular concentration, has been proposed to function as a second messenger [9, 10].”
Regulation of immune responses by L-arginine metabolism (2005, background): “H 2 O 2 originates from the conversion of O 2 − in contact with protons (H + ) in water (H 2 O), according to the following formula: 2O 2 − + 2H + ↔ H 2 O 2 + O 2 (Ref”