Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

By L. Harrington, R. D. Hatton, Paul R. Mangan, Henrietta Turner, T. Murphy, K. Murphy, C. Weaver. Nature Immunology, 2005

5,126 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/57a2a0eca4932ec081e13ae9f21ec18933a92628

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Citations in the corpus

• Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells (2009, background): “T H -17 cells have been characterized as a separate lineage of helper T cells able to produce IL-17A and IL-17F, as well as IL-22 and tumor necrosis factor (TNF”
• TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. (2006, background): “Indeed, a combination of anti-IL-12/23, anti-IFN-g, and anti-IL-4 was recently shown to support the development of IL-17-producing T cells ( Harrington et al., 2005; Park et al., 2005).”
• Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS) (2011, background): “However, the discovery of IL-23, the IL-12-related cytokine that shares the p40 subunit with IL-23, led to the re-evaluation of all previous work done with neutralization of p40 or with p40 knockout mice and to the eventual description of the Th17 cells that are stimulated by IL-23 and produce IL-17”
• IL-17 and Th17 Cells. (2009, background): “On the basis of this and other studies, investigators proposed that IL-17-producing T cells are a distinct T helper cell subset, which was named Th17 cells (9, 18, 19).”
• Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. (2006, background): “In addition, cytokines such as IL-17 do not fit well into the Th1/Th2 paradigm (Harrington et al., 2005).”
• FOLLICULAR HELPER T CELLS: LINEAGE AND LOCATION (2009, background): “Surprisingly, cell division appeared in both zones of the GC in contrast to classical models (Allen et al., 2007b; Hauser et al., 2007; Schwickert et al., 2007).”
• Inflammasomes and their roles in health and disease. (2012, background): “IL-18 also drives TH17 responses by facilitating the production of IL-17 from already committed TH17 cells cultured in the presence of IL-23 (Harrington et al. 2005, Weaver et al. 2006).”
• The Balance of Th17 versus Treg Cells in Autoimmunity (2018, background): “STAT3 also inhibits Treg cell differentiation by downregulating TGF-β-induced expression of Foxp3 [5,56,57].”
• Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. (2016, background): “TH17 cells are characterized by their expression of IL-17A, IL-17F, IL-6, IL-8, TNF-a, IL-22, and IL-26.”