TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

By M. Veldhoen, R. J. Hocking, C. Atkins, R. Locksley, Brigitta Stockinger. Immunity, 2006

3,794 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5bea094a910fa1796e3d56ed4f7b71f889ba1d71

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Citations in the corpus

• Regulatory T cells and immune tolerance. (2008, background): “Interestingly, TGF-β stimulation in the presence of IL-6 facilitates T cell differentiation to Th17 cells in mice (Veldhoen et al., 2006; Bettelli et al., 2006).”
• IL‐35 is a novel cytokine with therapeutic effects against collagen‐induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells (2007, methodology): “Cells were cultured with plate-bound anti-CD3 and anti-CD28 antibodies, TGF-b, IL-6, and IL-1b, as previously described [ 9 ].”
• Identification of IL-17-producing FOXP3+ regulatory T cells in humans (2009, background): “Signaling induced by these cytokines results in phosphorylation of STAT3 and expression of the orphan nuclear receptor ROR t, transcription factors that are required for induction of IL-17 expression (19, 20, 22).”
• Peripheral CD4 T cell differentiation regulated by networks of cytokines and transcription factors (2010, background): “IL-23 is important for full differentiation and maintenance of Th17 cells (36), although it is not involved in the initial differentiation stage due to lack of IL23R expression on naive CD4 T cells (8, 9, 37).”
• Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells (2007, background): “and the survival but not differentiation of T H -17 cell”
• The genetics and immunopathogenesis of inflammatory bowel disease (2008, background): “Further activation of these T cells by IL-23 is required for the survival and/or expansion of T H 17 cell”
• Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis1 (2009, background): “Since IL-23 is essential for Th17 survival and activity in vivo (37), we examined whether this IL23/IL-17 axis is involved.”
• IL-6 in inflammation, autoimmunity and cancer (2020, background): “The produced IL-6 further induces T h 17 cell differentiation through STAT3 in the presence of TGF β , IL-1 β and IL-23, all of which are rich in inflammatory lesions and tumor microenvironments (164, 166, 169–171, 174, 175).”
• Critical regulation of early Th17 cell differentiation by IL-1 signaling (2009, methodology): “We thus turned to a different Th17 cell differentiation system in which T cells were cocultured with dendritic cells (DCs) in the presence of soluble anti-CD3, LPS, and TGF-b (Veldhoen et al., 2006).”
• The Balance of Th17 versus Treg Cells in Autoimmunity (2018, background): “The effect of IL-6 is bolstered by other proinflammatory cytokines, including IL-1β, IL-21, IL-23, and TNF-α [3,53,58].”