Inflammasomes and their roles in health and disease.

By M. Lamkanfi, V. Dixit. Annual Review of Cell and Developmental Biology, 2012

910 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/112542f999ae398e17a8f614786147c191379911

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. M. Lamkanfi
2. G. Núñez
3. Hao Wu

In Molecular Biology

1. M. Lamkanfi
2. G. Núñez
3. V. Dixit
4. Yuan He
5. H. Hara
6. Katherine A. Fitzgerald
7. Heike Wulff
8. Rongbin Zhou

Citations in the corpus

• Unified Polymerization Mechanism for the Assembly of ASC-dependent Inflammasomes (2014, background): “The best-studied NLRP3 inflammasome is activated following a wide range of pathogen and danger signals, including extracellular ATP and uric acid crystals (Franchi et al., 2012; Lamkanfi and Dixit, 2012; Rathinam et al., 2012).”
• Mechanisms and functions of inflammasomes. (2014, background): “Interaction motifs belonging to the ''death domain'' superfamily bring the zymogens into the activating protein complex (Lamkanfi and Dixit, 2012; Riedl and Salvesen, 2007).”
• Role of neuroinflammation in neurodegeneration development (2023, background): “, ATP, uric acid, and aggregates).(348,349) Activating NLRP3 is a very complex process, which makes it unique among the inflammasomes.”
• Identification of fever and vaccine-associated gene interaction networks using ontology-based literature mining (2012, background): “Considering the roles of fever, such finding is reasonable [35-41].”
• Inflammasomes in neuroinflammatory and neurodegenerative diseases (2019, background): “…its role in the maturation of pro-IL-1b and pro-IL-18, caspase-1 can also induce a pro-inflammatory form of cell death, pyroptosis, that features early plasma membrane rupture, thereby releasing the soluble intracellular fraction that fuels the inflammatory response (Lamkanfi & Dixit, 2012, 2014).”
• Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. (2015, positive): “The activation of NLRP3 inflammasome promotes the maturation and release of several proinflammatory cytokines, such as interleukin-1b (IL-1b) and IL-18, so it plays critical roles in the initiation of inflammation and the development of immune responses (Lamkanfi and Dixit, 2012; Schroder and Tschop”
• Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders (2017, background): “In contrast to other sensor proteins, NLRP3 can sense many different factors derived from not only pathogen but also environment or host, so the aberrant activation of the NLRP3 inflammasome has been regarded as an important initiator or promoter in a variety of human complex diseases, including typ”
• Mechanism and regulation of NLRP3 inflammasome activation (2016, background): “However, dysregulated activation of the NLRP3 inflammasome has been implicated in the pathogenesis of inherited and acquired inflammatory diseases [10,11].”