Embryo-derived stem cells: of mice and men.

By Austin G Smith. Annual Review of Cell and Developmental Biology, 2001

1,357 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2090dc3d7fb6d5b0eb074dfc9dd91ae0faacea1d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

In Molecular Biology

Citations in the corpus

Ethical and Safety Issues of Stem Cell-Based Therapy (2018, background): “hESCs are stem cells derived from the pluripotent inner cell mass of the pre-implantation embryos [4, 5].”
The Transcriptional and Epigenomic Foundations of Ground State Pluripotency (2012, background): “Mouse embryonic stem (ES) cells are characterized by the potency to generate all somatic and germline lineages in vitro and in chimaeric embryos (Smith, 2001).”
Generation of pluripotent stem cells from neonatal mouse testis. (2004, neutral): “, and Smith, A. (2003). Functional expression cloning of Nanog, a GGGTTGTTTTATATTG-3 and 5 -ATAATACAACAACAACAATAACA pluripotency sustaining factor in embryonic stem cells.”
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (2008, background): “Mouse ES cells were first isolated in 1981 from mouse blastocysts (Smith, 2001).”
Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts (2008, neutral): “These stimuli may be provided in an integrated manner by a cellular microenvironment or by administration of cocktails of growth factors and cytokines in vitro (Smith, 2001).”
Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. (2006, neutral): “When allowed to differentiate in culture, ES cells generate embryoid bodies (EBs) that contain a broad spectrum of cell types representing derivatives of the three germ layers ( Smith, 2001 ).”
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. (2003, positive): “Although ES GDF cannot be excluded entirely, single cell clonogenic cells are a cell culture phenomenon, they are closely capacity of Id1 transfectant ES cells without added BMP related to pluripotent cells in the early mammalian emstrongly argues that Ids are the only essential BMP/ bryo (Brook and”
Klf4 reverts developmentally programmed restriction of ground state pluripotency (2009, background): “We conclude that ES cells differentiate into EpiSCs, although a minority of undifferentiated cells persists for a while, as is commonly observed in other in vitro ES cell differentiation schema (Lowell et al., 2006; Smith, 2001).”
Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, methodology): “In addition to their developmental potential in vivo, ES cells display a remarkable capacity to form differentiated cell types in culture (Keller 1995; Smith 2001).”
Stability and flexibility of epigenetic gene regulation in mammalian development (2007, background): “For example, early expression of genes such as Oct4 or Nanog is required for the establishment and maintenance of the inner-cell-mass lineage in the blastocys”
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells (2006, background): “Depending on culture conditions, these cells can differentiate into a variety of cell type”
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, background): “Because various differentiation programs occur simultaneously during EB cell differentiation (Smith 2001), standard clustering Table 1.”
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor (2004, background): “jpg" NDATA ITEM> ]> During early mammalian embryogenesis, the first critical fate decision, occurring between the late morula and blastocyst stages, divides the embryo into two major lineages: the pluripotent inner cell mass, which generates all three germ-layer tissues, and the trophobl”
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture (2003, result): “, but is consistent with the well-established role of gp130 cytokines in promoting self-renewal of undifferentiated ES cell”