The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

By Yuin Han Loh, Qiang Wu, Joon-Lin Chew, V. Vega, Weiwei Zhang, X. Chen, Guillaume Bourque, J. George, Bernard Leong, Jun Liu and 13 more. Nature Genetics, 2006

2,568 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6144385bdcb2009b9c1abd6f74921d0db83497d5

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Citations in the corpus

Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells (2007, background): “This concept is supported by chromatin immunoprecipitation (ChIP) studies in both human and mouse ES cells, suggesting that Oct3/4 and Sox2 cooperatively activate or repress a set of genes (including Oct3/4 , Sox2 and Nanog ) through their Oct–Sox enhancers; this, in turn, results in their coope”
Klf4 reverts developmentally programmed restriction of ground state pluripotency (2009, background): “Both cell types express the three transcriptional regulators, Oct4 (Pou5f1 – Mouse Genome Informatics), Sox2 and Nanog, that are generally considered to constitute the core pluripotency network (Boyer et al., 2005; Loh et al., 2006; Wang et al., 2006).”
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells (2011, background): “, 2008); however, neither this nor earlier studies (Boyer et al., 2005; Kim et al., 2008; Loh et al., 2006) identified Tet1 or Tet3 asOct4 target genes, possibly because the signals did not reach statistical significance.”
Mediator and Cohesin Connect Gene Expression and Chromatin Architecture (2010, neutral): “For example, Mediator was detected at the well-characterized enhancers of the Oct4 (Pou5f1) and Nanog genes 19 – 21 , which are bound by the ES cell master transcription factors Oct4, Sox2 and Nanog 22 , 23 .”
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (2008, methodology): “We demonstrate that the two key signaling pathways are integrated to the Oct4, Sox2, and Nanog circuitries through Smad1 and STAT3.”
A core Klf circuitry regulates self-renewal of embryonic stem cells (2008, background): “Oct4 and Sox2 have been shown to be critical for the self-renewal state of ES cell”
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells (2008, background): “Prior attempts to connect ES cell transcriptional regulators to miRNA genes have searched for transcription factor binding sites only close to the annotated mature miRNA sequences Cell 134, 521–533, August 8, 2008 ª2008 Elsevier Inc. 521 (Boyer et al., 2005; Loh et al., 2006; Lee et al., 2006).”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “A core set of transcription factors consisting of Oct4, Nanog, Sox2, and Tcf3 maintains the pluripotent state of ESCs (Boyer et al., 2005; Loh et al., 2006; Marson et al., 2008).”
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state (2007, background): “d, Western blot analysis for Oct4 and Nanog expression of different Oct4 iPS clones (6, 9, 10, 16, 18) and a GFP-labelled subclone of clone 18 (18.”
Transposable elements have rewired the core regulatory network of human embryonic stem cells (2010, background): “or have been restricted by the scope and comparability of the functional datasets being analyze”
Pluripotency: Toward a gold standard for human ES and iPS cells (2009, background): “Other factors required for pluripotency include Sall4, Dax1, Essrb, Tbx3, Tcl1, Rif1, Nac1 and Zfp281 (Ivanova et al., 2006; Loh et al., 2006; Wang et al., 2006; Zhou et al., 2007).”
Control of Embryonic Stem Cell State (2011, background): “The interconnected autoregulatory loop formed by Oct4, Sox2, and Nanog generates a bistable state for ESCs: residence in a positive-feedback-controlled gene expression program when the factors are expressed at appropriate levels, versus entrance into a differentiation program when any one of the mas”
Epigenetic reprogramming and induced pluripotency (2009, neutral): “D E V E LO P M E N T 517REVIEWDevelopment 136 (4) 2005; Loh et al., 2006) (Fig.”
Nanog Is the Gateway to the Pluripotent Ground State (2009, neutral): “Nanog is a highly divergent homeodomain-containing protein commonly accorded a central position in the transcriptional network of pluripotency (Boyer et al., 2005; Cole et al., 2008; Loh et al., 2006; Wang et al., 2006).”