Stability and flexibility of epigenetic gene regulation in mammalian development

By Wolf Reik. Nature, 2007

2,072 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/784ff3a6c5fc3f655eb6190afdeaac58886e43df

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Citations in the corpus

Epigenetic inheritance during the cell cycle (2009, background): “and during PGC development suggests, however, that DNA methylation can be removed by active mechanism”
CpG islands – ‘A rough guide’ (2009, background): “Some of these examples are known to play a key role in X-inactivation and genomic imprinting [57,58].”
In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions (2011, background): “Mole and erased in primordial germ cells (Reik, 2007).”
Epigenetics and the environment: emerging patterns and implications (2012, background): “These transitions contribute to the lineage- and tissue-specific expression of gene”
Epigenetic regulation of neurogenesis in the adult mammalian brain (2011, background): “(Dnmts) is responsible for the catalysis of DNA methylation (Goll & Bestor, 2005; Reik, 2007).”
450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy (2012, background): “HEALTH PERSPECTIVES National Institutes of Health U.S. Department of Health and Human Services”
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain (2011, neutral): “Cytosine methylation is catalyzed by a family of DNA methyltransferases (DNMTs), and deficiencies in these enzymes result in profound developmental defects (Goll and Bestor, 2005; Reik, 2007).”
Dynamic DNA methylation programs persistent adverse effects of early-life stress (2009, background): “DNA methylation is one of the most intensely studied epigenetic mechanism”
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (2010, background): “In mammals, the dimorphic gametes differ greatly in their potential to transmit epigenetic information encoded in histones and the associated post-translational modification”
Aberrant epigenetic landscape in cancer: how cellular identity goes awry. (2010, background): “…occur immediately after fertilization and during early preimplantation development (Mayer et al., 2000; Reik et al., 2001) and that enrichment of individual histone modifications (such as H3K9me, H3K4me and H3K27me3) also varies in a specific manner at different stages of development (Reik, 2007).”
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. (2008, background): “These epigenetic mechanisms would in turn stabilize cell-typespecific gene expression patterns and reduce the likelihood that stem cell-specific or lineage-unrelated genes will be reactivated (Reik, 2007).”
Urbanization, oxidative stress and inflammation: a question of evolving, acclimatizing or coping with urban environmental stress (2015, background): “DNA methylation is the most intensively studied epigenetic mechanism (Reik 2007), and most commonly refers to the addition of a methyl group to the 5-position of a cytosine ring.”
Epigenetic events in mammalian germ-cell development: reprogramming and beyond (2008, background): “During somatic cell differentiation, cells start in a pluripotent state and make a series of decisions about their fates, thereby giving rise to a range of cell type”
Psychological Stress in Childhood and Susceptibility to the Chronic Diseases of Aging: Moving Towards a Model of Behavioral and Biological Mechanisms (2011, background): “Over the course of development, the DNA of mammalian species undergoes several phases of epigenetic remodeling (Reik, 2007).”