BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3.

By Qi-Long Ying, Jennifer Nichols, Ian Chambers, Austin G Smith. Cell, 2003

2,235 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7fa779ef385b024a2c43f6c294eff23e9e0ae997

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Citations in the corpus

Embryonic stem cells (2004, background): “These protocols have since been further simplified to remove the EB stage and differentiate murine and human ES cells into neuroectodermal lineages in monolayer, the only somatic cell type for which this is known to be possible (Reubinoff et al. 2001; Pachernik et al. 2002; Ying et al. 2003).”
Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell (2005, background): “Mouse ES cells differentiate efficiently into neural precursor cells upon withdrawal of serum in adherent monolayer culture [8] or via treatment of embryoid bodies with retinoic acid [30,31].”
Wnt signaling and stem cell control (2008, neutral): “inhibitors of differentiation (Id) genes (Ying et al. 2003).”
How is pluripotency determined and maintained? (2007, background): “, 2003), neuronal differentiation (Ying et al., 2003) and mesoderm differentiation (Suzuki et al.”
A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy (2011, background): “Bone morphogenetic protein 7 (BMP-7), a member of the TGF-β superfamily, acts in opposition to the classical profibrogenic effects of TGF-β1 (92), perhaps because some of the BMPs induce Id proteins that inhibit differentiation or DNA binding via the Smad1/5 pathway, and these proteins may act as ne”
High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells (2009, background): “Id genes are sufficient for maintenance of murine embryonic stem cell self-renewal and pluripotency in the absence of bone morphogenetic protein (Ying et al., 2003).”
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. (2007, background): “, 2005) but is involved in self renewal of mouse ES cells (Ying et al., 2003).”
A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog (2009, background): “The Inhibition of Differentiation genes Id1, Id2, and Id3 are repressed by Tgf-β signaling in mES cells (Ying et al., 2003).”
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells (2005, background): “LIF signalling, which is essential for mESC self renewal (Chambers and Smith, 2004), is not active in undifferentiated hESCs (Daheron et al., 2004; Humphrey et al., 2004).”
Germline Competent Embryonic Stem Cells Derived from Rat Blastocysts (2008, positive): “We recently demonstrated that bone morphogenetic proteins (BMPs) can replace serum and act together with LIF to maintain mouse ES cell self-renewal (Ying et al., 2003).”
Capture of authentic embryonic stem cells from rat blastocysts. (2008, positive): “However, the key parameter determining derivation and propagation of mouse ES cells appears to be suppression or neutralization of extrinsic differentiation signals ( Ying et al., 2003a, 2008 ), rather than provision of a self-renewal stimulus.”