Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

By N. Sato, L. Meijer, L. Skaltsounis, Paul Greengard, Ali H. Brivanlou. Nature Medicine, 2004

2,217 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f72f00f36c589d4127fd2ad328b4d80cfef4e999

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In Molecular Biology

Citations in the corpus

TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells (2005, methodology): “We have previously shown that BIO is able to maintain mESCs as well as hESCs in the undifferentiated state (Sato et al., 2004).”
Heparan sulfate proteoglycans. (2011, background): “Interestingly, many of the signaling molecules involved in stem cell maintenance, such as Wnts and FGFs, are regulated by HSPGs (Sato et al. 2004; Xu et al. 2005a,c).”
Wnt signalling in stem cells and cancer (2005, background): “Modulation of Wnt signalling by controlling the dose of APC, or by treatment with a GSK3-β inhibitor, can enhance self-renewal of both mouse and human embryonic stem cell”
Gene function in mouse embryogenesis: get set for gastrulation (2007, background): “Inhibition of GSK3 (glycogen synthase kinase 3), which enhances WNT signalling by increasing the nuclear accumulation of β-catenin , promotes maintenance of the undifferentiated state of ES cell”
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism (2005, methodology): “Our findings also provide a potential mechanism for how the GSK3 inhibitor 6-bromoindirubin-3′-oxime (BIO) promotes self-renewal of ES cells (Sato et al., 2004).”
Epigenetic reprogramming and induced pluripotency (2009, background): “Moreover, Wnt pathway activation has beneficial effects not only on the growth of ES cells (Sato et al., 2004), but also for the reprogramming of somatic cells into pluripotent cells by transcription factors (Marson et al., 2008) and for cell fusion between somatic cells and ES cells (Lluis et al.,…”
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance (2005, background): “The Wnt signaling pathway regulates stem cell fate in a variety of organs besides the hematopoietic system, specifically embryonic stem cell”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “Inhibition of GSK3, on the other hand, promotes mESCs propagation (Sato et al., 2004).”
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells (2005, background): “Wnt signalling is so far the only pathway reported to be active in maintaining pluripotency in both species (Sato et al., 2004), but Wnt activity alone is not sufficient to maintain pluripotency of hESCs (James et al.”
Functional redundancy of GSK-3α and GSK-3β in wnt/β-catenin signaling shown by using an allelic series of embryonic stem cell lines (2007, background): “The differentiation block that we observe in the DKO ES cells is consistent with the report of Sato et al. which suggested that Wnt signaling or GSK-3 inhibition could maintain pluripotency of mouse and human ES cells (Sato et al., 2004).”
Embryonic stem cells: prospects for developmental biology and cell therapy. (2005, background): “Recently, two groups identified the homeodomain protein Nanog as another key regulator of pluripotentiality (73, 233).”