Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.

By M. Jin, Sung Eun Kim, J. Heo, Mi Eun Lee, Ho Min Kim, S. Paik, Hayyoung Lee, Jie-Oh Lee. Cell, 2007

1,362 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/180b3bfae1611a965a8690cd4edb1bd308d7c3c1

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Citations in the corpus

Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “This receptor complex flexibility allows TLR2 to recognize a diverse set of ligands (Table 4) (29, 99).”
Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. (2009, methodology): “This dimeric arrangement is found in all known TLR homo- or heterodimer structures and supports the hypothesis that dimerization of the extracellular domains enforces juxtaposition and activation of the intracellular TIR domains ( Jin et al., 2007; Liu et al., 2008; Park et al., 2009).”
Molecular Basis of NF-κB Signaling (2013, background): “To date, several structures of the extracellular domain of TLRs bound to a ligand have been solved and reveal a common overall structure (45, 49, 67, 90, 130).”
A cell biological view of Toll-like receptor function: regulation through compartmentalization (2009, background): “Moreover, the recruitment of MYD88 to the plasma membrane is functionally important, as an allele of MYD88 that is directed to the plasma membrane (generated by the addition of an n-terminal ptdIns(4,5)p2-binding domain) restored lipopolysaccharide (Lps) responsiveness in TIRApdeficient macrophages ”
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “Studies have provided structural insights into the mechanisms by which these heterodimers discriminate the structures of lipoprotein”
The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress (2008, background): “The structure of the TLR1/2 dimer in association with triacylated lipopeptide ligand has been solved (63).”
The Role of TLR2 in Infection and Immunity (2012, background): “In the absence of TLR1 and TLR6, TLR2 homodimerization was proposed but it has not been observed with current techniques (Jin et al., 2007).”
Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens (2010, background): “In addition, as the two lipid chains of LTA are thought to mediate the interaction with the lipid-binding pocket of TLR2 (Ref”
Pathogen Recognition by the Innate Immune System (2011, background): “Of the TLRs, TLR1, 2, 4, 5, 6, 7, and 9 are primarily dedicated to the recognition of various bacterial components.”
Pattern recognition receptors in health and diseases (2021, background): “The ligand-binding pocket of TLR1–TLR2 is located in the interface between the central and C-terminal domain, and TLR1–TLR2–tri-acylated lipopeptide is stabilized by non-covalent bonds such as hydrogen bonds, hydrophobic interactions, and ionic interactions near the ligand-binding pocket.(62) In TLR”
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “directly bind to triacetylated lipopeptides, double-stranded RNA (dsRNA), and CpG DNA, respectively (159, 202, 216),”