The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress

By Luke A. O'Neill. Immunological Reviews, 2008

639 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8392e6892e9cff9a1fb46aa609c97738cf80a1ed

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In Immunology

Citations in the corpus

Molecular Basis of NF-κB Signaling (2013, background): “Upon initial binding to IL-1R1, association with IL-1RAcP is required for tight binding of the cytokine and downstream signaling (57, 87, 102).”
Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View (2013, background): “Likewise, IL-1 is released primarily from activated macrophages in a timely manner similar to TNF-α, signals through two distinct receptors, termed IL-1 receptor type I (IL-1R1) and IL-1R2, and has comparable downstream effects on immune cells [44, 47].”
Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “TLRs are key innate immune receptors to perceive pathogen-associated molecular patterns (PAMPs), which are specific pathogenic “molecular signature” [6].”
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. (2014, background): “IL-1R belongs to the IL-1R/TLR superfamily due to the presence a conserved cytoplasmic Toll/IL-1R (TIR) domain [10].”
Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “[153,193], resulting in transcriptional regulation of cytokine production and other proinflammatory processes.”
Defining Postpartum Uterine Disease and the Mechanisms of Infection and Immunity in the Female Reproductive Tract in Cattle (2009, neutral): “The most important group of such receptors comprises the TLRs, and 10 members of the receptor family are widely encoded in the mammalian genome and are most often found in a broad range of immune cells [3, 4].”
Periodontitis: a polymicrobial disruption of host homeostasis (2010, background): “Second, the identification of the Toll-like receptor (TLR) family of receptors, which recognize microorganisms, has contributed to the realization that both commensal and periopathogenic bacteria can activate innate immune response”
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. (2011, background): “(13) The release of mature IL-1 , the IL-1 precursor, and the contents of the secretory lysosomes by exocytosis in the absence of cell death.”