A cell biological view of Toll-like receptor function: regulation through compartmentalization
By G. Barton, Jonathan C. Kagan. Nature reviews. Immunology, 2009
754 citations recorded by the source corpus.
An emerging paradigm in innate immune signalling is that cell biological context can influence the outcome of a ligand–receptor interaction. In this Review we discuss how Toll-like receptor (TLR) activation and signal transduction are regulated by subcellular compartmentalization of receptors and downstream signalling components. In particular, we focus on the functional specialization of TLRs in the endosomal system. We discuss recent studies that illustrate how basic aspects of the cellular machinery contribute to TLR function and regulation. This emerging area of research will provide important information on how immune signal transduction networks depend on (and in some cases influence) the generic regulators that organize eukaryotic cells.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/8af35ed7461d364e66585180a9720a7acf015e07
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
- Shizuo Akira
- Taro Kawai
- O. Takeuchi
- Jonathan C. Kagan
- Zhijian J. Chen
- R. Medzhitov
- G. Barton
- I. Zanoni
Citations in the corpus
- The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance (2011, background): “Thus, while the specific release of proinflammatory cytokines by macrophages during infection is a critical mechanism for a protective immune respons”
- Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “First, innate immune responses can be compartmentalized and regulated by both the structural and dynamic features of a cell (14).”
- Peroxisomes are signaling platforms for antiviral innate immunity (2010, positive): “In the TLR network, however, signaling occurs from a variety of different organelles, not just one (Barton and Kagan, 2009).”
- Pattern recognition receptors and inflammation. (2010, background): “Accumulating evidence underscores the importance of the localization of TLRs in the cell for their recognition by ligand (Barton and Kagan, 2009).”
- CD14 controls the LPS-induced endocytosis of Toll-like Receptor 4 (2011, background): “Different TLR family membersare found indifferent subcellular compartments, ranging from the plasma membrane to early, late, and recycling endosomes (Barton and Kagan, 2009).”
- Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. (2011, background): “…delivered to intracellular vesicles to form a complex with TRAM and TRIF, which then recruits TRAF3 and the protein kinases TBK1 and IKKi, which catalyze the phosphorylation of IRF3, leading to the expression of type I IFN Immunity 34, May 27, 2011 ª2011 Elsevier Inc. 639 (Barton and Kagan, 2009).”