Innate Immune Pattern Recognition: A Cell Biological Perspective

By Sky W. Brubaker, Kevin S. Bonham, I. Zanoni, Jonathan C. Kagan. Annual Review of Immunology, 2015

1,371 citations recorded by the source corpus.

Receptors of the innate immune system detect conserved determinants of microbial and viral origin. Activation of these receptors initiates signaling events that culminate in an effective immune response. Recently, the view that innate immune signaling events rely on and operate within a complex cellular infrastructure has become an important framework for understanding the regulation of innate immunity. Compartmentalization within this infrastructure provides the cell with the ability to assign spatial information to microbial detection and regulate immune responses. Several cell biological processes play a role in the regulation of innate signaling responses; at the same time, innate signaling can engage cellular processes as a form of defense or to promote immunological memory. In this review, we highlight these aspects of cell biology in pattern-recognition receptor signaling by focusing on signals that originate from the cell surface, from endosomal compartments, and from within the cytosol.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/7a8d9f882dee378110c9809c68fe0671e14274ce

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Citations in the corpus

Bacterial outer membrane vesicles mediate cytosolic localization of LPS and caspase-11 activation (2016, positive): “The compartmentalization of the innate immune system enables it to mount customized immune responses to pathogens based on the subcellular localization of microbial products (Brubaker et al., 2015).”
Mitochondrial DNA in inflammation and immunity (2020, neutral): “PRRs can be broadly classified into four distinct groups: NOD-like receptors (NLRs), Toll-like receptors (TLRs), retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) and C-type lectin receptors (CLRs) [1].”
Immunity, inflammation, and cancer: an eternal fight between good and evil. (2015, positive): “Both PAMPs and DAMPs are recognized by pattern-recognition receptors (PRRs), many of which belong to the TLR family (5, 6).”
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA (2015, background): “…or danger-associated molecular patterns (PAMPs or DAMPs) and trigger molecular cascades that together initiate and orchestrate the cellular response through activation of e.g. interferon regulatory factors and nuclear factor kB (Brubaker et al., 2015; Pandey et al., 2015; Wu and Chen, 2014).”
Pattern recognition receptors in health and diseases (2021, background): “The activation of PRRs brings double-sided effects: on the one hand, it stimulates innate immunity and adaptive immunity to resist pathogenic microorganisms; on the other hand, it promotes the expression of a large number of cytokines, forms an inflammatory microenvironment, and causes tissue damage”