The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

By Taro Kawai, Shizuo Akira. Nature Immunology, 2010

9,047 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5285648acfd4ab315127faf3829f50cf0e92428b

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In Immunology

Citations in the corpus

Programmed cell death in the plant immune system (2011, background): “Typical animal extracellular PRRs, called Toll-like receptors (TLRs) possess an intracellular Toll-interleukin-1 (IL-1) receptor domain (TIR) that recruits the kinases IRAK or RIP via adaptor proteins, inducing expression of antimicrobial defense molecules.(5) These kinases belong to the same functi”
Pattern recognition receptors in health and diseases (2021, background): “TLRs are type I transmembrane glycoproteins and are composed of an extracellular region, a transmembrane region, and an intracellular region.(44) The extracellular region contains leucine-rich repeats (LRRs), which are responsible for the recognition of specific ligands and perform extracellular pat”
Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3–mediated pathway (2011, background): “Recognition of poly(I:C) and LPS by TLR3 and TLR4, respectively, induces NF-κB activation and the subsequent induction of cytokines, such as TNF-α (20), which may indirectly lead to TNF-α–dependent necrosis similar to Smac mimetic-induced necrosis (21).”
Immunological mechanisms of vaccination (2011, background): “The innate immune system can sense microbes through pattern-recognition receptors (PRRs), such as the Toll-like receptors (TLRs), which are expressed by various cells, including dendritic cells (DCs”
TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria (2012, positive): “TRIF is an integral component of TLR3 and TLR4 signaling (Kawai and Akira, 2010) and also functions in an RNA-sensing pathway involving DDX1, DDX21, and DHX6 (Zhang et al.”
NF-κB signaling in inflammation (2017, positive): “34 This pathway involves recruitment of TRAF proteins, particularly TRAF3, to TRIF and subsequent activation of TANK-binding kinase 1 (TBK1) and IKK ε in a mechanism that is thought to involve TRAF3 ubiquitination and ubiquitin-dependent recruitment of TBK1 and IKK ε .”
Origins, structures, and functions of circulating DNA in oncology (2016, background): “It involves the receptors being implicated in recognizing particular molecular motifs derived from pathogenic organisms: the pathogen-associated motif pattern (PAMP) [213].”
Trained immunity: a program of innate immune memory in health and disease (2016, background): “Unlike lymphocytes, innate immune cells do not express rearranging antigen receptor genes, but they do express pattern recognition receptors (PRRs) and other receptors that allow them to recognize and respond to pathogen-derived structures (pathogen-associated molecular patterns, PAMPs) and endogeno”
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. (2012, background): “C) AP-1.”
Innate immunity in the central nervous system. (2012, neutral): “18 –20) .”