Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.

By J. Kang, Xue-Ping Nan, M. Jin, S. Youn, Y. Ryu, S. Mah, S. Han, Hayyoung Lee, S. Paik, Jie-Oh Lee. Immunity, 2009

763 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/4153b63a15f80a50a738c189dca557fc46c9aee7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

Citations in the corpus

Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling (2014, background): “It is a single-spanning transmembrane protein with an extracellular domain composed of 22 leucine-rich repeats conferring a horseshoe-like shape on the protein, found typical for TLRs by crystallography studies [6–8].”
Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “This receptor complex flexibility allows TLR2 to recognize a diverse set of ligands (Table 4) (29, 99).”
Pattern recognition receptors in health and diseases (2021, background): “2a, b).(63) Researches on the structure of ligand complexes can significantly promote the discovery of small molecule agonists/antagonists targeting PRRs.”
The Role of TLR2 in Infection and Immunity (2012, background): “This has been described in detail by crystallographic techniques, demonstrating that the TLR1 ectodomain has a channel that binds the amide-bound lipid chain of the triacylated LP (Jin et al., 2007), while the same channel in TLR6 is obstructed by amino acid residues (Kang et al., 2009).”
The Structural Biology of Toll-Like Receptors (2011, background): “Formation of the homo- or heterodimer supports the hypothesis that dimerization of the ECDs positions the cytoplasmic TIR domains close enough to dimerize and initiate a downstream signaling cascade (Jin et al., 2007;Kang et al., 2009;Liu et al., 2008;Park et al., 2009).”
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “Studies have provided structural insights into the mechanisms by which these heterodimers discriminate the structures of lipoprotein”
Molecular Basis of NF-κB Signaling (2013, background): “To date, several structures of the extracellular domain of TLRs bound to a ligand have been solved and reveal a common overall structure (45, 49, 67, 90, 130).”