Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

By J. C. Yoon, P. Puigserver, Guoxun Chen, Jerry Donovan, Zhidan Wu, James Rhee, G. Adelmant, John M. Stafford, C. Kahn, D. Granner and 2 more. Nature, 2001

1,921 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/111e41edd4ff359e2f4bfd0abad511562a424bef

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Citations in the corpus

Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “In addition to its role in the thermogenic program, the coactivator is also markedly induced in mouse liver in response to fasting where it activates the genes encoding gluconeogenic enzymes (239).”
PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism (2020, background): “Indeed mice with liverspecific mutations in the insulin receptor present high PGC-1α levels in the liver, which demonstrates the key role of insulin as a suppressor of PGC-1α [45, 49].”
Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “However, PGC-1 expression is known to vary in several instances, including fasting, upon stimulation of the cAMP signaling pathway and in type 2 diabetes animal models (354).”
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. (2006, background): “…adaptive thermogenesis in brown adipose tissue (BAT) (Puigserver et al., 1998), fiber-type switching in skeletal muscle (Lin et al., 2002), and both b-oxidation of fatty acids and gluconeogenesis in liver (Herzig et al., 2001; Puigserver et al., 2003; Rhee et al., 2003; Yoon et al., 2001).”
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. (2006, background): “In these tissues, increased PGC-1 levels can account for elevated gluconeogenesis and decreased insulin secretion in diabetes, respectively (21, 77).”
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. (2010, background): “This increase in NAD content correlates with increased SIRT1mediated deacetylation and activation of the coactivator PGC-1 (82), which then promotes gluconeogenesis by coactivating a set of transcription factors, including hepatocyte nuclear factor-4 (104), glucocorticoid receptor (105), and FOXOs (”
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. (2006, background): “However, hepatic PGC1A and PGC1B gene expression is robustly induced by fasting (39, 50, 70).”
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine (2005, background): “Finally, in the energy-homeostasis tissue, liver, PGC1α interacts with FOXO1, HNF-4α, and the glucocorticoid receptor (GR) to induce gluconeogenesis enzymes, including phosphoenolpyruvate carboxylase (PEPCK) and glucose-6-phosphatase (G6Pase) to maintain basal blood glucose levels (78, 121, 187, 254”
Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis (2012, background): “Yoon JC, et al. (2001) Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.”
Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation Published, JLR Papers in Press, April 16, 2005. DOI 10.1194/jlr.M400373-JLR200 (2005, background): “The PGC-1 pathway plays a crucial role in the transcriptional regulation of hepatic gluconeogenic enzymes (36, 37) and in the differentiation of brown fat cells.”
The world of protein acetylation. (2016, background): “receptor-coactivator 1-alpha (PGC-1-alpha) is an important transcription factor regulating gluconeogenesis in fasting and diabetes [339].”
Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle (2003, background): “Subsequent studies revealed that PGC-1a is also expressed in liver and skeletal muscle tissue where it co-activates the transcription of genes required for gluconeogenesis and mitochondrial biogenesis, respectively (Wu et al. 1999; Yoon et al. 2001).”