Role of bile acids and bile acid receptors in metabolic regulation.

By P. Lefebvre, B. Cariou, F. Lien, F. Kuipers, Bart Staels. Physiological Reviews, 2009

1,650 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/a7f3b715c6447806e9f4f0a5feb185f046362843

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. F. Bäckhed
2. V. Tremaroli
3. A. Ramachandran
4. P. Kovatcheva-Datchary
5. M. Ståhlman
6. Christoph Borner
7. Hanns-Ulrich Marschall
8. J. Y. Chiang

In Oncology

1. J. Y. Chiang
2. Christoph Borner
3. Hanns-Ulrich Marschall
4. P. Edwards
5. F. Bäckhed
6. David S. Wishart

In Surgery

1. F. Bäckhed
2. A. Ramachandran
3. J. Y. Chiang
4. Hanns-Ulrich Marschall
5. H. Jaeschke
6. P. Edwards

Citations in the corpus

• Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation (2013, background): “, 2010) and the various FMO genes are also thought to function as phase I xenobiotic genes (Lefebvre et al., 2009).”
• Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes. (2011, background): “Besides favoring dietary lipid absorption, different bile acids exert several other metabolic regulatory functions (48, 49).”
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “In hepatocytes, FXR is an important regulator of bile acid synthesis, detoxification and transport (for recent reviews including overviews of FXR target genes see (Calkin and Tontonoz 2012; Modica et al. 2010; Lefebvre et al. 2009; Keitel et al. 2008a; Thomas et al. 2008; Kalaany and Mangelsdorf 200”
• Pleiotropic Roles of Bile Acids in Metabolism (2013, background): “We refer those interested to many excellent related reviews on bile acids, FXR, or TGR5 (Angelin et al., 2012; Chiang, 2009; Keitel and Häussinger, 2012; Lefebvre et al., 2009; Matsubara et al., 2013; Pols et al., 2011b; Porez et al., 2012; Russell, 2003, 2009; Thomas et al., 2008).”
• Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation (2015, background): “Bile acids are cholesterol metabolites that facilitate the absorption of dietary fat and fat-soluble molecules and are now also recognized as regulators of energy metabolism through activation of the receptors TGR5 and FXR (Hylemon et al., 2009; Lefebvre et al., 2009).”
• Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. (2013, background): “Importantly, in this study, OCA induced a marked doserelated increase in plasma levels of FGF19, a primary FXRresponsive transcriptional product.(11) It is noteworthy that FGF19 is not up-regulated by ursodeoxycholic acid,(44) a BA with no FXR agonistic activity(26) that is used to treat primary bil”
• Bile acids: regulation of synthesis (2009, background): “glucose, drug, and energy metabolism [Review in (8-15)].”