The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.

By R. Houtkooper, C. Cantó, R. Wanders, Johan Auwerx. Endocrine reviews, 2010

902 citations recorded by the source corpus.

Subfields: Geriatrics and Gerontology, Oncology, Physiology

View Paper: https://www.semanticscholar.org/paper/9cd58396ccaf5e3a8a18073ea5fd15480b636b91

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Geriatrics and Gerontology

1. Johan Auwerx
2. E. Verdin
3. C. Cantó
4. R. Houtkooper
5. Keir J. Menzies
6. L. Guarente
7. A. Sauve
8. E. Pirinen

In Oncology

1. Johan Auwerx
2. C. Cantó
3. J. Campisi
4. Adam Freund
5. E. Verdin
6. R. Houtkooper
7. L. Guarente
8. J. Y. Chiang

In Physiology

1. E. Verdin
2. Johan Auwerx
3. C. Cantó
4. R. Houtkooper
5. Keir J. Menzies
6. Adam Freund
7. J. Campisi
8. E. Pirinen

Citations in the corpus

• Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease (2018, positive): “Sirtuins 1 and 3 using NAD+ as the cosubstrate elicits various metabolic improvements in many tissues (lung, spleen, brain, and small intestine) [28].”
• NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential (2020, background): “The similar depletion rate of free NAD in the cytoplasm and nucleus supports the notion regarding a probable exchange of NAD between these compartments, while a slower rate of free NAD depletion in mitochondrial suggests that the mitochondrial NAD pool is segregated from the cytosolic and nuclear po”
• Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes (2015, background): “…(NADH, NADP, and NADPH) have many functions in cells, such as serving as hydride donors and acceptors in redox reactions (Belenky et al., 2007; Houtkooper et al., 2010), participation in bacterial and DNA ligase reactions (Wilkinson et al., 2001), and roles as molecules that signal the…”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, methodology): “NAD+ can also be synthesized from metabolite recycling or the dietary uptake of other NAD+ precursors (Houtkooper et al., 2010a).”
• Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype (2015, background): “While mitochondria oxidize NADH generated by the tricarboxylic acid (TCA) cycle or fatty acid oxidation, they also oxidize the cytosolic NAD +/NADH pool through the a-glycerophosphate and malate-aspartate shuttles (Houtkooper et al., 2010).”
• The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling (2013, positive): “Our data suggest that augmenting mitochondrial stress signaling through the modulation of NAD+ levels may be a target to improve mitochondrial function and prevent or treat age-associated decline.”
• Acetyl-CoA and the Regulation of Metabolism: Mechanisms and Consequences (2015, background): “Another example is NAD+, which indicates the cellular redox status as a ratio of NAD+ to NADH [4,5].”
• The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity (2012, positive): “NRKs initiate NR metabolism into NAD+ (Houtkooper et al., 2010).”