The world of protein acetylation.
By Adrian Drazic, Line M. Myklebust, Rasmus Ree, T. Arnesen. Biochimica et Biophysica Acta, 2016
701 citations recorded by the source corpus.
Acetylation is one of the major post-translational protein modifications in the cell, with manifold effects on the protein level as well as on the metabolome level. The acetyl group, donated by the metabolite acetyl-coenzyme A, can be co- or post-translationally attached to either the α-amino group of the N-terminus of proteins or to the ε-amino group of lysine residues. These reactions are catalyzed by various N-terminal and lysine acetyltransferases. In case of lysine acetylation, the reaction is enzymatically reversible via tightly regulated and metabolism-dependent mechanisms. The interplay between acetylation and deacetylation is crucial for many important cellular processes. In recent years, our understanding of protein acetylation has increased significantly by global proteomics analyses and in depth functional studies. This review gives a general overview of protein acetylation and the respective acetyltransferases, and focuses on the regulation of metabolic processes and physiological consequences that come along with protein acetylation.
Subfields: Geriatrics and Gerontology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/6b5b4d2ee97ef1d28f52bee09b211a9c3736a89d
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Citations in the corpus
- Post-Translational Modifications That Drive Prostate Cancer Progression (2021, background): “Protein acetylation is also associated with protein degradation and it can regulate a variety of signaling pathways as well as the cell cycle [292].”
- How RNA binding proteins interact with RNA: molecules and mechanisms (2020, background): “At the molecular level, PTMs introduce electrostatic charges that can affect the structural stability of binding regions or their ability to interact with RNA or other proteins (Drazic et al., 2016; Law et al., 2003; Lovci et al., 2016).”