Transcriptional paradigms in mammalian mitochondrial biogenesis and function.

By R. Scarpulla. Physiological Reviews, 2008

1,660 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/c8d73d8b6ad405fb849bf569265bb7014d976bda

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. John S. Mattick
2. Marcel E. Dinger
3. Tim R. Mercer
4. R. Scarpulla
5. C. V. Dang
6. Q. Ma
7. B. Spiegelman
8. G. Shadel

In Physiology

1. R. Scarpulla
2. C. V. Dang
3. J. Little
4. M. Gibala
5. Q. Ma
6. B. Spiegelman
7. G. Shadel
8. T. Horvath

Citations in the corpus

• MYC on the Path to Cancer (2012, background): “Mitochondrial biogenesis could be stimulated in normal cells by NRF1, which binds E boxes and is a target of Myc (Scarpulla, 2008).”
• The human mitochondrial transcriptome (2011, positive): “Given that transcription termination is the key mechanism that determines the ratio of mitochondrial rRNA to mRNA expression (Scarpulla, 2008), we next considered whether termination also modulates light strand expression stoichiometry .”
• Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging (2009, background): “In addition, mitochondrial transcription factor A (TFAM) and nuclear respiratory factor 1 (NRF1), key transcription factors in mitochondrial biosynthesis (16), are also reduced during aging (Fig.”
• Role of nrf2 in oxidative stress and toxicity. (2013, background): “For mitochondrial biogenesis, endogenous carbon monoxide generated by HO-1 stimulates MnSOD upregulation and mitochondrial H2O2 production to activate Akt/PKB; Akt deactivates GSK-3β, which activates Nrf2; Nrf2 binds to the four AREs in the enhancer of the gene encoding NRF-1 to induce NRF-1; NRF-1 ”
• Mitochondrial DNA mutations and human disease. (2010, background): “In-depth reviews on mtDNA transcription are available [36,37].”
• Mitochondrial ROS signaling in organismal homeostasis. (2015, background): “Thus, mitochondrial biogenesis and homeostasis, including mtDNA expression and maintenance, are under strict control of nuclear gene expression programs (Scarpulla, 2008).”
• MYC, Metabolism, and Cancer. (2015, background): “Although factors that control mitochondrial biogenesis for homeostasis have been well established, the means by which mitochondrial biogenesis occurs in response to cell growth has only more recently been proposed (169).”
• A practical model of low‐volume high‐intensity interval training induces mitochondrial biogenesis in human skeletal muscle: potential mechanisms (2010, background): “PGC-1α and Tfam appear to play integral roles regulating transcription of mitochondrial genes in the nucleus and mitochondria, respectively (Hood et al. 2006; Scarpulla, 2006, 2008).”
• Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network (2010, background): “The properties of these proteins have been reviewed and will not be considered in detail here [7,17].”