Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle
By H. Pilegaard, B. Saltin, P. Neufer. Journal of Physiology, 2003
988 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/cfcd1b8c9719249cceb8ba7d511772014a74e71c
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Citations in the corpus
- Acute exercise remodels promoter methylation in human skeletal muscle. (2012, background): “Exercise increases the messenger RNA (mRNA) expression and protein levels of a plethora of genes regulating mitochondrial function and fuel usage, including PGC-1a, transcription factor A, mitochondrial (TFAM); peroxisome proliferator-activated receptor d (PPAR-d); and pyruvate dehydrogenase kinase,”
- Mitochondrial dynamics in mammalian health and disease. (2009, background): “Exposure to cold, treatment with CL-316243, or exercise enhance Ppargc1a (PGC-1 ) expression in tissues (33, 238, 244).”
- PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. (2006, background): “PGC-1α in response to acute bouts of exercise or endurance training (38, 66) and have indicated that PGC-1α levels are increased mainly in type IIa fibers after endurance training (66).”
- Short‐term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance (2006, background): “’ With regards to human muscle, several groups have described changes in the expression of PGC-1α and other metabolic transcriptional co-activators and transcription factors after acute exercise (Pilegaard et al. 2003; Russell et al. 2005; Coffey et al. 2006); however, no studies have directly compa”
- Transcriptional control of mitochondrial biogenesis and function. (2009, background): “NRF-1 induction by exercise has not been seen in human studies, which may reflect species differences, the types of muscle tested, or the type and duration of physical activity (24, 25).”
- Adaptive thermogenesis in adipocytes: is beige the new brown? (2013, background): “PGC-1a is induced during exercise (Pilegaard et al. 2003; Russell et al. 2003) and regulates many exercise-related pathways in skeletal muscle (Lin et al. 2002; Sandri et al. 2006; Handschin et al. 2007; Wu et al. 2011).”
- Exercise metabolism and the molecular regulation of skeletal muscle adaptation. (2013, background): “Transient postexercise changes in gene transcription include immediate early genes, myogenic regulators, genes of carbohydrate (CHO) metabolism, lipid mobilization, transport and oxidation, mitochondrial metabolism and oxidative phosphorylation, and transcriptional regulators of gene expression and ”
- Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans (2008, background): “Acute exercise induces transient transcriptional activation of the PGC-1α gene in human skeletal muscle (Pilegaard et al. 2003) but to our knowledge only one previous study in humans has examined the effect of prolonged exercise on PGC-1α protein content.”
- The role of exercise and PGC1α in inflammation and chronic disease (2008, background): “Accordingly, the expression of this gene, PGC1A (also known as PPARGC1A ), is rapidly induced after a single bout of endurance exercis”
- Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. (2004, background): “…shown that PGC-1 gene expression is induced by exercise in rodent and human skeletal muscle (Goto et al. 2000; Baar et al. 2002; Terada et al. 2002; Terada and Tabata 2003; Pilegaard et al. 2003) and by short-term starvation in the heart and liver of mice (Lehman et al. 2000; Rhee et al. 2003).”