PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

By B. Finck, D. Kelly. Journal of Clinical Investigation, 2006

1,433 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Endocrinology, Diabetes and Metabolism, Physiology

View Paper: https://www.semanticscholar.org/paper/133bbbe84e8c778f2b449320d2dceaadc650e647

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Citations in the corpus

Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF (2013, positive): “…and oxidative phosphorylation are well known to be controlled by the members of the peroxisome proliferator-activated receptor g coactivator 1 (PGC-1) family of transcriptional coactivators (PGC1a, PGC1b, PPRC1) (Lin et al., 2005a; Finck and Kelly, 2006; Handschin, 2009; Leone and Kelly, 2011).”
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway (2013, background): “PGC-1a is induced by exercise in skeletal muscle, and is a major mediator of the beneficial effects of exercise in this tissue (Finck and Kelly, 2006).”
Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis (2010, background): “receptors (ERRs), PPARs, or nuclear respiratory factors (NRFs) [1,2,3,4].”
The emerging role of Nrf2 in mitochondrial function (2015, background): “The second class of nuclear transcriptional regulators with critical functions in mitochondrial biogenesis are transcriptional coactivators, such as peroxisome proliferator-activated receptor γ coactivators (PGC)1α and 1β, which interact with transcription factors, the basal transcriptional and RNA-”
CPT1A-mediated fat oxidation, mechanisms and therapeutic potential. (2020, background): “Additionally, PGC-1 also functioned as a coactivator in the thyroid induction of CPT1A in the liver (58), highlighting the pleotropic roles of PGC-1 in lipid metabolism (59).”
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network (2010, background): “Massive increases in mitochondrial content both in cultured cells and in mouse tissues upon over expression of either PGC-1 or PGC-1β is thought to occur through coactivator interactions with key transcription factors (NRF-1, NRF-2, ERRα) in promoting the expression of genes required for the biogene”
The Molecular Bases of Training Adaptation (2007, background): “Proposed effects of acute endurance and resistance training on forkhead box O1 (FoxO1) mediated transcription activation.”
Transcriptional paradigms in mammalian mitochondrial biogenesis and function. (2008, background): “These have been ascribed to differences in genetic background or targeting strategies (68).”
Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. (2015, positive): “An emerging idea is that generating a new “metabolic sink” for glucose, triglycerides, and possibly other metabolites through promoting beige adipocyte development can phosphorylation gene program (59).”
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes (2008, background): “Conversely, PPARγ activity can be enhanced by the PPARγ co-activator-1α (PGC-1α), initially identified through its interaction with PPARγ in brown fa”
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α (2007, background): “PGC-1a is a metabolic coactivator that by interacting with transcription factors induces mitochondrial biogenesis and respiration (Lin et al, 2005; Finck and Kelly, 2006).”