Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.

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Transcriptional control of mitochondrial biogenesis and function. (2009, background): “The molecular mechanisms are best characterized for PGC-1α and include the ability to recruit the histone acetyltransferases CBP/p300 and Mediator (9).”
The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism (2014, background): “PGC1α is a transcriptional co-activator for most genes in the TCA cycle and ETC, and thus is a master regulator of mitochondrial respiration and oxidative metabolism [86].”
The role of exercise and PGC1α in inflammation and chronic disease (2008, background): “From these studies, it is clear that PGC1α is a key mediator of many of the known beneficial effects of physical activity on skeletal muscle physiolog”
Mitochondrial Dysfunction in Neurodegenerative Diseases (2012, background): “We showed a pathologic grade-dependent significant reduction in numbers of mitochondria in striatal spiny neurons, which correlated with reductions in PGC-1␣ and Tfam (Kim et al., 2010).”
The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity (2010, background): “In addition, adiposePGC1a andPGC1bgene expression levels were highly elevated in caspase-1-deficient animals (Figure 4C), implying an increase in mitochondrial activity and energy expenditure (Handschin and Spiegelman, 2006).”