The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.

By A. Ozinsky, D. Underhill, J. Fontenot, A. Hajjar, Kelly D. Smith, Christopher B Wilson, Lea Schroeder, Alan Aderem. Proceedings of the National Academy of Sciences of the United States of America, 2000

2,317 citations recorded by the source corpus.

Subfields: Emergency Medical Services, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/0c6eb6b5746171c53ebeaa57ff0c8d5c707d47b9

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Citations in the corpus

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway (2002, background): “TLR6 can associate with TLR2 and recognize peptidoglycan (PGN) and lipopeptides derived from Mycoplasm”
Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock (2003, background): “tive lipopeptides and lipoproteins (211, 407, 516, 603).”
TIRAP: an adapter molecule in the Toll signaling pathway (2001, background): “Thus, the TIR domain of TLR4 signals as a homodimer, whereas the TIR domain of TLR2 can only signal as a heterodimer in combination with TLR1 or TLR”
Signals of recent positive selection in a worldwide sample of human populations. (2009, background): “pathogens (Ozinsky et al. 2000), is among the highly differentiated SNPs in this cluster (Fig.”
The interleukin‐1 receptor/Toll‐like receptor superfamily: 10 years of progress (2008, background): “TLR2 will dimerize with either TLR1 or TLR6, recognizing distinct ligands (59).”
Innate Immune Pattern Recognition: A Cell Biological Perspective (2015, neutral): “TLR2 mainly acts as a heterodimer in association with other TLRs (96), and its function depends on its TLR-binding partner, any coreceptor involved in the recognition process, and the type of bound ligand.”
Innate immune sensing and its roots: the story of endotoxin (2003, background): “It is believed generally that the highly homologous TLRs TLR1 and TLR6 form heterodimeric complexes with TLR2 (Ref”
Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins1 (2002, neutral): “Notably, TLR6 has a unique property to recognize a mycoplasmal lipoprotein cooperatively with TLR2 (12, 13).”
Silica crystals and aluminum salts mediate NALP-3 inflammasome activation via phagosomal destabilization (2008, background): “Commercial zymosan preparations are known to activate signaling pathways dependent on Toll-like receptor 2 and dectin 1 (refs”
Innate immune recognition. (2002, background): “Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.”