Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins1

By O. Takeuchi, Shintaro Sato, T. Horiuchi, K. Hoshino, K. Takeda, Z. Dong, R. Modlin, Shizuo Akira. Journal of Immunology, 2002

1,497 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/004c118d94df02b05acbaa70b62c4fe90d8b63bb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. S. Ghosh
2. Shizuo Akira
3. M. Hayden
4. A. West
5. B. Beutler
6. K. Hoebe
7. N. Perkins
8. M. Karin

In Immunology

1. Shizuo Akira
2. S. Ghosh
3. M. Hayden
4. B. Beutler
5. A. West
6. K. Hoebe
7. Xin Du
8. Taro Kawai

In Public Health, Environmental and Occupational Health

1. Daniel M Altmann
2. S. Sriskandan
3. Shizuo Akira

Citations in the corpus

• Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis. (2007, background): “Another member of the toll-like receptor family, TLR-2, has been shown to play a role in lipid trafficking via uptake of diacylated lipoproteins [30], a process that requires CD36 [21].”
• Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. (2006, background): “…TLR expression to predict the efficiency of responsiveness to particular TLR ligands because many TLR are intracellular and coreceptor components could influence avidity of receptor-ligand interactions (Matsumoto et al., 2003, Latz et al., 2004, Takeuchi et al., 2001, and Takeuchi et al., 2002).”
• Pathogen recognition and innate immunity. (2006, neutral): “LTA, an amphiphilic, negatively charged glycolipid, also contains a diacylated moiety and activates the cells via the TLR2/TLR6 heterodimer (Alexopoulou et al., 2002; Ozinsky et al., 2000; Takeuchi et al., 2001, 2002).”
• NF-κB and the immune response (2006, background): “Recent reports have demonstrated that triacylated lipoproteins from bacteria are preferentially recognized by the TLR1/TLR2 complex, whereas diacylated lipoproteins are recognized by the TLR2/TLR6 complex (Takeuchi et al., 2002).”
• The immunology of sepsis (2008, background): “Experiments using whole S. aureus demonstrate that cellular responses to the bacterium reside to a large extent in response to the diacylated lipoprotein of the cell surface, recognized by TLR2 and TLR6 [29–31].”