Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

By H. Hemmi, T. Kaisho, O. Takeuchi, Shintaro Sato, H. Sanjo, K. Hoshino, T. Horiuchi, H. Tomizawa, K. Takeda, Shizuo Akira. Nature Immunology, 2002

2,684 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/dec11fad3e406411dd3eae739e6364ab8840c421

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In Immunology

1. Shizuo Akira
2. S. Ghosh
3. M. Hayden
4. A. West
5. B. Beutler
6. R. Randall
7. S. Goodbourn
8. R. Medzhitov

Citations in the corpus

• Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, background): “The ligands for TLR7 include immunomodulatory compounds such as imiquimod and R848 (Hemmi et al., 2002; Jurk et al., 2002; Heil et al., 2003) and single-stranded RNA (ssRNA) molecules, either synthetic (Diebold et al., 2004) or derived from viruses such as human immunodeficiency virus (HIV),…”
• Innate immune sensing and its roots: the story of endotoxin (2003, background): “cgi?l=17874">MyD88 as a transducer of signals initiated by diverse TLR”
• NF-κB and the immune response (2006, background): “Although initially found to recognize synthetic antiviral compounds, namely imidazoquinolines, the azoquinoline R-848 and loxoribine (Hemmi et al., 2002; Jurk et al., 2002), TLR7 and human TLR8 are now known to recognize guanosine- or uridine-rich singlestranded RNA derived from RNA viruses…”
• How we detect microbes and respond to them: the Toll‐like receptors and their transducers (2003, background): “Finally, although an authentic microbial product has not yet been identified for TLR7, small, antiviral molecules with a nucleoside structure (imiquimod and resiquimod) were shown to stimulate cells via TLR7 [44].”
• Dendritic-cell control of pathogen-driven T-cell polarization (2003, background): “TLR7 ligands in mice and humans are imiquimod (Aldara, R-837, S-26308) and R-848 (resiquimod, S-28463), both low-molecular-weight compounds of the imidazoquinoline family that have potent anti-viral and antitumour properties in animal model”
• Recognition of microbial infection by Toll-like receptors. (2003, background): “Jurk M, Heil F, Vollmer J, Schetter C, Krieg AM, Wagner H, Lipford G, Bauer S: Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848.”