Innate immune recognition.

By C. Janeway, R. Medzhitov. Annual Review of Immunology, 2002

8,796 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3270c6d4ea39e4884d80e7e385e1b6386da15193

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In Epidemiology

In Immunology

Citations in the corpus

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway (2003, background): “TLRs are abundantly expressed on professional antigen-presenting cells such as macrophages and dendritic cells, and serve as an important link between the innate and adaptive immune response”
Macrophage migration inhibitory factor: a regulator of innate immunity (2003, background): “Natural host defences against microorganisms are mediated by the innate immune system — the most ancient of the two branches of the immune syste”
IKKε and TBK1 are essential components of the IRF3 signaling pathway (2003, background): “Discussion Activation of innate immunity requires the integration of complex networks of signal transduction pathways, leading to the induction of specific sets of genes in response to many different infectious microorganism”
Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility (2003, background): “It is widely assumed that the innate immune system recognizes pathogen-associated molecular patterns (PAMPs) that are conserved on microbial pathogens, required for microbial fitness and not represented in the hos”
DC-SIGN: escape mechanism for pathogens (2003, background): “Specific receptors for pathogen recognition Immature DCs screen for pathogen entry using conserved PRRs, which recognize characteristic molecular patterns in microbial cell-wall components, such as carbohydrate structures, or lipids or nucleic acid”
In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination (2004, background): “Second, DCs become potent stimulators of immunity after undergoing a complex differentiation or maturation program in response to a panel of stimuli including microbial ligands for toll-like receptors (9, 10), innate lymphocytes (11, 12), and CD40 ligation (13).”
Mammalian defensins in the antimicrobial immune response (2005, background): “The efficient sensing of microbes is mainly the result of binding of pathogen-associated molecular patterns by Toll-like receptors (TLRs) and other pattern-recognition molecules on host cells or in plasm”