TIRAP: an adapter molecule in the Toll signaling pathway

By T. Horng, G. Barton, R. Medzhitov. Nature Immunology, 2001

1,091 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/1fb153ed5a44f896e91945be685cc4113c202c14

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Shizuo Akira
2. K. Takeda
3. R. Medzhitov
4. Jonathan C. Kagan
5. G. Barton
6. O. Takeuchi
7. T. Kaisho
8. Jacques Deguine

In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. O. Takeuchi
4. Taro Kawai
5. K. Takeda
6. Jonathan C. Kagan
7. G. Barton
8. T. Mogensen

In Oncology

1. Shizuo Akira
2. O. Takeuchi
3. R. Medzhitov
4. K. Takeda
5. Jonathan C. Kagan
6. R. Randall
7. S. Goodbourn
8. G. Barton

Citations in the corpus

• Toll-like receptors in innate immunity. (2004, neutral): “A database search for molecules that are structurally related to MyD88 led to identification of the second TIR domain-containing molecule TIRAP (TIR domain-containing adaptor protein)/Mal (MyD88-adaptor-like) (79,80).”
• NFκB-dependent signaling pathways (2002, background): “It controls the activation of MyD88-independent signaling pathways downstream of TLR4 [102,103].”
• TLR signaling pathways. (2004, background): “Database search analyses led to the identification of a second TIR domain-containing molecule, which was named TIRAP or Mal[45,46].”
• Toll-like receptors. (2003, background): “MOLECULES INVOLVED IN THE MYD88-INDEPENDENT PATHWAY In the course of analyzing the MyD88-independent activation of LPS signaling, a novel adaptor molecule named TIR domain–containing adaptor protein (TIRAP)/MyD88adaptor-like (Mal) was identified (215, 216).”