The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease

By Youcun Qian, Caini Liu, J. Hartupee, C. Z. Altuntas, M. F. Gulen, Dan Jane-wit, Jianhua Xiao, Yi Lu, N. Giltiay, Jinbo Liu and 8 more. Nature Immunology, 2007

631 citations recorded by the source corpus.

Subfields: Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/0a0a6c5222fafce9d611483c7486810873de41de

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In Immunology

1. D. Cua
2. V. Kuchroo
3. F. Quintana
4. S. Gaffen
5. C. Dong
6. T. Korn
7. M. Oukka
8. M. McGeachy

In Pathology and Forensic Medicine

1. D. Cua
2. S. Gaffen
3. V. Kuchroo
4. M. McGeachy
5. T. Korn
6. C. Dong
7. E. Bettelli
8. M. Oukka

Citations in the corpus

• The biological functions of T helper 17 cell effector cytokines in inflammation. (2008, neutral): “Indeed , Act1 binds to the cytoplasmic domain of IL-17RA (Chang et al., 2006b) and is a functional adaptor critical for IL-17RA signaling and the development of EAE and dextran-sodium-sulfateinduced colitis (Qian et al., 2007).”
• The IL-17 family of cytokines in health and disease (2019, background): “TRAF6 also promotes activation of MAPK/AP1 pathways and the C/EBPβ and δ transcription factors (Chang et al., 2006; Maitra et al., 2007; Qian et al., 2007; Ruddy et al., 2004).”
• TH17 cells in development: an updated view of their molecular identity and genetic programming (2008, background): “ACT1-deficient mice were resistant to experimental autoimmune encephalomyelitis (EAE), as well as colitis induced by dextran sulphate sodium (DSS”
• Astrocytes: Key Regulators of Neuroinflammation. (2016, background): “IL17 binding to heteromeric transmembrane receptors results in the recruitment of NFkB activator 1 (Act1) and formation of a signaling complex which triggers the production of pro-inflammatory cytokines, chemokines and metalloproteinases [36].”
• Structure and signalling in the IL-17 receptor superfamily (2009, neutral): “Co-immunoprecipitation studies indicate that ACT1 is recruited to IL-17RA within 5 minutes of IL-17A stimulatio”
• Evidence for a cross-talk between human neutrophils and Th17 cells. (2010, background): “Act1 is an essential component of the IL-17-dependent signaling pathway that ultimately drives the induction of cytokine and chemokine gene expression.(28) For this reason, we established that, in human neutrophils, Act1 is not only expressed at the mRNA (Fig.”
• A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 (2010, background): “Of these genes, TRAF3IP2 encodes ACT1, an adaptor protein essential for IL17-dependent NF-κB activation and Th17-mediated inflammatory response”
• IL-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability (2015, neutral): “K18creAct1 mice were provided by Xiaoxia Li and have been described previously (Qian et al., 2007; Swaidani et al., 2009) All animal procedures were approved by the Institutional Animal Care and Use Committee of Merck Research Laboratories in accordance with guidelines of the Association for Assessm”
• Astrocyte crosstalk in CNS inflammation (2020, background): “Nuclear translocation of NF-κB in astrocytes is triggered by pro-inflammatory stimuli such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-17 (Qian et al., 2007), reactive oxygen species (ROS) (Chandel et al.”
• IL-17 and Th17 Cells. (2009, background): “The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease.”