The biological functions of T helper 17 cell effector cytokines in inflammation.
By Wenjun Ouyang, J. Kolls, Yan Zheng. Immunity, 2008
1,802 citations recorded by the source corpus.
Subfields: Immunology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/4d78d06bfbac67d84f72310cd320c47273a492d1
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In Pathology and Forensic Medicine
Citations in the corpus
- The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling (2011, background): “Functional analysis of LTi cells has unexpectedly shown that these cells produce IL-17 and/or IL-22, which are involved in tissue remodeling and immunit”
- Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells (2009, background): “IL-17 is considered an inflammatory cytokine and has been associated with many autoimmune disorder”
- Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “In the process of DC-mediated polarization of different Th subsets, IL-12 plays a critical role in inducing Th1 responses, most notably IFN- (368), whereas IL-23 and IL-1 in humans, and transforming growth factor and IL-6 in mice, participate in inducing Th17 responses with preferential secretion of”
- Cytokine signaling modules in inflammatory responses. (2008, neutral): “The pathways for generating IL-22 are discussed in accompanying reviews in this issue by Ouyang et al. (2008), Li and Flavell (2008), and McGeachy and Cua (2008).”
- Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine (2008, positive): “…to participate in inflammatory responses and to have critical functions in host defense against bacterial and fungal pathogens, particularly those encountered at mucosal surfaces (Aujla et al., 2007, 2008; Bettelli et al., 2007; Khader et al., 2007; McKenzie et al., 2006; Ouyang et al., 2008).”
- Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells (2009, positive): “Evidence is accumulating that IL-22 is important in epithelial cell homeostasis and in infection and inflammation, as well as in tissue repair and wound healin”
- STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing (2009, background): “IL-22 has been described to be produced by activated T cells, especially by Th17 cells as well as by DCs and NK cells (Wolk and Sabat, 2006; Ouyang et al., 2008).”
- Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation (2011, positive): “Th17 cells play a prominent role not only in resistance against intestinal pathogens such as Shigella or Citrobacter (Ouyang et al., 2008), but also in autoimmune and inflammatory disorders in the gastrointestinal tract including Crohn’s disease and ulcerative colitis (Ahern et al., 2008).”
- AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch (2011, background): “A key protective factor is interleukin 22 (IL-22), which acts on mucosal epithelial cells, inducing their survival, proliferation and secretion of antimicrobial peptide”
- Critical regulation of early Th17 cell differentiation by IL-1 signaling (2009, background): “Interestingly, IL-1induced IL-22 expression in Th17 cells differentiated in the presence of exogenous TGF-b, suggesting the plasticity of IL-22 expression.”
- Evidence for a cross-talk between human neutrophils and Th17 cells. (2010, background): “Th17 cells also produce IL-17F, as well as other cytokines and chemokines, including IL-21, IL-22, IL-26 and CCL20 (reviewed in Ouyang et al.(1) and Tesmer et al.”