Structure and signalling in the IL-17 receptor superfamily

By S. Gaffen. Nature reviews. Immunology, 2009

1,388 citations recorded by the source corpus.

Interleukin-17A (IL-17A), the hallmark cytokine of the newly defined T helper 17 (TH17) cell subset, has important roles in protecting the host against extracellular pathogens, but also promotes inflammatory pathology in autoimmune disease. IL-17A and its receptor (IL-17RA) are the founding members of a newly described family of cytokines and receptors that have unique structural features which distinguish them from other cytokine families. Research defining the signal transduction pathways induced by IL-17R family cytokines has lagged behind that of other cytokine families, but studies in the past 2 years have begun to delineate unusual functional motifs and new proximal signalling mediators used by the IL-17R family to mediate downstream events.

Subfields: Cancer Research, Immunology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/be05ab3452fa6eaca9a74a18bd4fd5e2b7d58e9b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. D. Cua
2. Adriana Rendon
3. K. Schäkel
4. C. Tato
5. Huiyuan Zhang

In Immunology

1. D. Cua
2. S. Gaffen
3. C. Tato
4. A. Garg
5. Nilesh Amatya
6. K. Futosi
7. Szabina Fodor
8. K. Schäkel

In Pathology and Forensic Medicine

1. D. Cua
2. C. Tato
3. S. Gaffen
4. Adriana Rendon
5. K. Schäkel
6. A. Garg
7. Nilesh Amatya

Citations in the corpus

• STAT3 signaling in immunity (2016, background): “of immune effectors such as anti-microbial peptides, chemokines and granulopoietic cytokines [208,209].”
• Innate IL-17-producing cells: the sentinels of the immune system (2010, background): “We now have a fundamental understanding of how the IL-17R signalling pathway, through the adaptor molecule ACT1 (also known as CIKS) and the transcription factor nuclear factor- κB (NF-κB), induces downstream mediators, including IL-6, CXCL8 and CC-chemokine ligand 20 (CCL20”
• Inflammation, Immunity, and Hypertensive End-Organ Damage (2015, background): “These receptor chains are thought to heterodimerize on ligand binding and signal through the adaptor molecule Act1 and tumor necrosis receptor–associated factor-6, leading to nuclear factor kappa B, mitogen-activated protein kinase and CCAAT-enhancer–binding protein-δ activation.(35) Importantly, IL”
• Psoriasis Pathogenesis and Treatment (2019, background): “In nail psoriasis and psoriatic arthritis (PsA), an increased expression of TNF-α, NFκB, IL-6, and IL-8 in psoriasis-affected nails is consistent with the inflammatory markers found on lesional psoriatic skin [73].”
• Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “Further details on TGFβ-receptor signal transduction [178,179] and IL17-mediated inflammatory responses and IL-17 receptor signaling [180–184] can be found in excellent recent reviews.”
• Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. (2012, neutral): “Oral or intramuscular glucocorticoids 5 (13) 4 (10) 3 (8) 4 (10) 5 (12) 16 (10)”
• IL-17 Signaling: The Yin and the Yang (2017, background): “IL-17 signaling does not activate the non-canonical NF-κB pathway [30].”