T. Tchkonia

Physiology · 2010–2022

A researcher in the Science corpus: 21 papers; trusts 18 researchers and is trusted by 6 researchers here, as inferred from the citation graph.

Subfields

Physiology — 274 citations into it; #464 of 2,276 by trust here, #64 by citations
Molecular Biology — 190 citations into it
Immunology — 101 citations into it; #1,318 of 2,160 by trust here, #405 by citations
Aging — 63 citations into it; #177 of 261 by trust here, #73 by citations
Cancer Research — 47 citations into it
Dermatology — 24 citations into it

Whom T. Tchkonia trusts overall

Their strongest outbound trust, strongest first, inferred from their citations.

Who trusts T. Tchkonia overall

Papers from T. Tchkonia's perspective

Ordered by how strongly the researchers T. Tchkonia trusts endorse each paper. Same corpus, a different order for every researcher.

Senescence of activated stellate cells limits liver fibrosis (Cell)
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas (Nature)
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders (Nature)
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence (Nature Cell Biology)
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation (Journal of Cell Science)
Inflammatory Networks during Cellular Senescence: Causes and Consequences (Trends in Molecular Medicine)
Cellular Senescence in Aging Primates (Science)
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence (Nature Communications)
Obesity is associated with macrophage accumulation in adipose tissue. (Journal of Clinical Investigation)
DNA damage response and cellular senescence in tissues of aging mice (Aging Cell)

Their papers

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors (2016) — 1,003 citations
Cellular senescence drives age-dependent hepatic steatosis (2017) — 924 citations
Cellular senescence and senolytics: the path to the clinic (2022) — 888 citations
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues (2021) — 803 citations
Senolytic drugs: from discovery to translation (2020) — 992 citations
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease (2019) — 1,153 citations
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study (2019) — 1,080 citations
Senolytics Improve Physical Function and Increase Lifespan in Old Age (2018) — 1,970 citations
Fisetin is a senotherapeutic that extends health and lifespan (2018) — 892 citations
Cellular Senescence: A Translational Perspective (2017) — 902 citations
Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice (2017) — 671 citations
Identification of HSP90 inhibitors as a novel class of senolytics (2017) — 620 citations
Targeting cellular senescence prevents age-related bone loss in mice (2017) — 1,011 citations
Cellular senescence mediates fibrotic pulmonary disease (2017) — 1,412 citations
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice (2016) — 685 citations
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs (2015) — 2,184 citations
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age (2015) — 792 citations
Mechanisms and Metabolic Implications of Regional Differences among Fat Depots (2013) — 648 citations
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. (2013) — 1,571 citations
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders (2011) — 3,430 citations