DNA damage response and cellular senescence in tissues of aging mice

By Chunfang Wang, D. Jurk, M. Maddick, Glyn Nelson, C. Martin-Ruiz, T. von Zglinicki. Aging Cell, 2009

680 citations recorded by the source corpus.

Subfields: Dermatology, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/35e76e0af7c3d83039e63961a23b8dfdd89c56aa

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Dermatology

1. J. Campisi
2. Manuel Serrano
3. M. Blasco
4. J. Kirkland
5. T. Tchkonia
6. M. Demaria

In Endocrine and Autonomic Systems

1. J. Campisi
2. Guido Kroemer
3. Linda Partridge

In Physiology

1. J. Campisi
2. J. Kirkland
3. M. Demaria
4. T. Tchkonia
5. Manuel Serrano
6. Adam Freund
7. Guido Kroemer
8. Nathan K. LeBrasseur

Citations in the corpus

• The hallmarks of aging. (2013, background): “Similar results were obtained in the skin, lung, and spleen, but no changeswere observed in heart, skeletal muscle, and kidney (Wang et al., 2009).”
• Lamin B1 loss is a senescence-associated biomarker (2012, methodology): “We chose liver because previous reports showed an accumulation of senescent cells in this tissue (Paradis et al., 2001; Xue et al., 2007; Krizhanovsky et al., 2008; Wang et al., 2009; Le et al., 2010), and liver showed low background staining, allowing for accurate quantitation.”
• A senescent cell bystander effect: senescence-induced senescence (2012, methodology): “2F) and Sen-b-Gal (Wang et al., 2009, 2010) and allows clear cell boundary definition in the low magnification tiled images necessary for cluster analysis.”
• Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Various markers of senescence, including SA- -gal, p16, and DDR, accumulate in tissues of aged mammals including rodents (42, 189, 335), baboons (156, 168), and humans (67, 97, 211, 225, 267), suggesting that senescent cells CELLULAR SENESCENCE”
• JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age (2015, background): “Senescent cells accumulate with aging in the skin (13, 14), liver (15, 16), kidney (17), the cardiovascular system (18), and other tissues in various species (16).”
• Aging, Cellular Senescence, and Cancer (2012, background): “Persistent DNA damage foci are found in tissues that experience genotoxic stress (42) and in aging mouse and primate tissues (29, 30, 84).”