J. Kirkland
Physiology · 2010–2022
A researcher in the Science corpus: 24 papers; trusts 26 researchers and is trusted by 7 researchers here, as inferred from the citation graph.
Subfields
- Physiology — 342 citations into it; #413 of 2,276 by trust here, #59 by citations
- Molecular Biology — 273 citations into it; #17,753 of 17,773 by trust here, #6,028 by citations
- Immunology — 117 citations into it; #1,343 of 2,160 by trust here, #405 by citations
- Aging — 77 citations into it; #179 of 261 by trust here, #63 by citations
- Oncology — 72 citations into it
- Cancer Research — 59 citations into it
- Genetics — 48 citations into it
- Dermatology — 28 citations into it
Whom J. Kirkland trusts overall
Their strongest outbound trust, strongest first, inferred from their citations.
- T. Tchkonia
- Yi Zhu
- J. Campisi
- D. Baker
- T. Kuilman
- Jean-Philippe Coppé
- T. Pirtskhalava
- J. Passos
- M. Demaria
- Bennett G. Childs
Who trusts J. Kirkland overall
Papers from J. Kirkland's perspective
Ordered by how strongly the researchers J. Kirkland trusts endorse each paper. Same corpus, a different order for every researcher.
- Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders (Nature)
- Senescence of activated stellate cells limits liver fibrosis (Cell)
- Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas (Nature)
- Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence (Nature Cell Biology)
- Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence (Nature Communications)
- Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation (Journal of Cell Science)
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors (Aging Cell)
- Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). (American Journal of Physiology. Heart and Circulatory Physiology)
- Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. (Journal of Clinical Investigation)
- Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis (Nature)
Their papers
- Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors (2016) — 1,003 citations
- Senescence and apoptosis: dueling or complementary cell fates? (2014) — 803 citations
- Cellular senescence drives age-dependent hepatic steatosis (2017) — 924 citations
- Cellular senescence: the good, the bad and the unknown (2022) — 946 citations
- Cellular senescence and senolytics: the path to the clinic (2022) — 888 citations
- A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues (2021) — 803 citations
- Senolytic drugs: from discovery to translation (2020) — 992 citations
- Sarcopenia: Aging-Related Loss of Muscle Mass and Function. (2019) — 1,466 citations
- Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease (2019) — 1,153 citations
- Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study (2019) — 1,080 citations
- Senolytics Improve Physical Function and Increase Lifespan in Old Age (2018) — 1,970 citations
- Fisetin is a senotherapeutic that extends health and lifespan (2018) — 892 citations
- Cellular Senescence: A Translational Perspective (2017) — 902 citations
- Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice (2017) — 671 citations
- Identification of HSP90 inhibitors as a novel class of senolytics (2017) — 620 citations
- Targeting cellular senescence prevents age-related bone loss in mice (2017) — 1,011 citations
- Cellular senescence mediates fibrotic pulmonary disease (2017) — 1,412 citations
- Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice (2016) — 685 citations
- The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs (2015) — 2,184 citations
- JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age (2015) — 792 citations