R. DePinho

Molecular Biology · 2000–2018

A researcher in the Science corpus: 41 papers; trusts 37 researchers and is trusted by 29 researchers here, as inferred from the citation graph.

Subfields

• Molecular Biology — 543 citations into it; #2,397 of 17,773 by trust here, #472 by citations
• Oncology — 260 citations into it; #787 of 1,698 by trust here, #194 by citations
• Genetics — 156 citations into it
• Cancer Research — 138 citations into it; #842 of 1,780 by trust here, #262 by citations
• Physiology — 116 citations into it; #176 of 2,276 by trust here, #257 by citations
• Immunology — 83 citations into it
• Epidemiology — 42 citations into it; #1,405 of 2,148 by trust here, #1,155 by citations
• Aging — 35 citations into it; #68 of 261 by trust here, #76 by citations

Whom R. DePinho trusts overall

Their strongest outbound trust, strongest first, inferred from their citations.

1. C. Kenyon
2. Elizabeth H Blackburn
3. Derrick J. Rossi
4. T. de Lange
5. Toren Finkel
6. Irving L. Weissman
7. C. Sherr
8. G. Bergers
9. Thomas B. L. Kirkwood
10. K. Dorshkind

Who trusts R. DePinho overall

1. Ralph Weissleder
2. D. Hanahan
3. C. Folmes
4. N. Bardeesy
5. Alberto Ciccia
6. R. Shaw
7. J. Llovet
8. R. Weinberg
9. M. Pittet
10. F. Furnari

Papers from R. DePinho's perspective

Ordered by how strongly the researchers R. DePinho trusts endorse each paper. Same corpus, a different order for every researcher.

1. Cell intrinsic alterations underlie hematopoietic stem cell aging. (Proceedings of the National Academy of Sciences of the United States of America)
2. The plasticity of aging: insights from long-lived mutants. (Cell)
3. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells (Nature)
4. Prospective identification of tumorigenic breast cancer cells (Proceedings of the National Academy of Sciences of the United States of America)
5. Increased Wnt Signaling During Aging Alters Muscle Stem Cell Fate and Increases Fibrosis (Science)
6. Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging (Science)
7. Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation (PLoS Biology)
8. Rejuvenation of aged progenitor cells by exposure to a young systemic environment (Nature)
9. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. (Science)
10. The hallmarks of cancer (RNA Biology)

Their papers

• The LKB1 tumor suppressor negatively regulates mTOR signaling. (2004) — 1,144 citations
• Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. (2004) — 595 citations
• Malignant astrocytic glioma: genetics, biology, and paths to treatment. (2007) — 2,428 citations
• The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin (2005) — 2,021 citations
• Glutamine supports pancreatic cancer growth through a Kras-regulated metabolic pathway (2013) — 1,842 citations
• Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a (2006) — 1,103 citations
• International network of cancer genome projects (2010) — 2,229 citations
• FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. (2007) — 1,101 citations
• Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. (2004) — 850 citations
• Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis (2001) — 859 citations
• Connecting chromosomes, crisis, and cancer. (2002) — 595 citations
• Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. (2003) — 1,048 citations
• Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. (2006) — 602 citations
• Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies (2007) — 962 citations
• Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development (2000) — 603 citations
• HDAC2 negatively regulates memory formation and synaptic plasticity (2009) — 1,612 citations
• Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. (2006) — 684 citations
• How stem cells age and why this makes us grow old (2007) — 866 citations
• BRafV600E cooperates with Pten silencing to elicit metastatic melanoma (2009) — 929 citations
• Linking functional decline of telomeres, mitochondria and stem cells during ageing (2010) — 748 citations