International network of cancer genome projects

By T. Hudson, W. Anderson, Axel Artez, A. Barker, C. Bell, R. Bernabé, M. Bhan, F. Calvo, I. Eerola, D. Gerhard and 249 more. Nature, 2010

2,229 citations recorded by the source corpus.

The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/94b1beafd5fa39b46492d6ec8e96868ec7416d6d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Peter J. Campbell
2. S. Nik-Zainal
3. David C. Wedge
4. Gad Getz
5. Ludmil B. Alexandrov
6. Michael R. Stratton
7. Christoph Bock
8. C. López‐Otín

In Molecular Biology

1. Aviv Regev
2. Peter J. Campbell
3. Christoph Bock
4. S. Nik-Zainal
5. Garry P. Nolan
6. Dana Pe'er
7. Michael R. Stratton
8. K. Polyak

Citations in the corpus

• Mutational Processes Molding the Genomes of 21 Breast Cancers (2012, background): “There are seven APOBEC3 proteins in humans, with the prototype (APOBEC3G) as well as several other APOBEC3s acting on lentiviral replication intermediates constituting an innate pathway of antiretroviral defense (Hultquist et al., 2011; Sheehy et al., 2002).”
• Analysing and interpreting DNA methylation data (2012, methodology): “DNA methylation mapping will often complement genome sequencing and transcriptome mapping, as in the studies of the International Cancer Genome Consortium 139 .”