Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging

By Hongjun Liu, M. Fergusson, R. M. Castilho, Jie Liu, Liu Cao, Jichun Chen, D. Malide, I. Rovira, D. Schimel, C. Kuo and 3 more. Science, 2007

777 citations recorded by the source corpus.

Subfields: Genetics, Nephrology, Urology

View Paper: https://www.semanticscholar.org/paper/e129ae24d784e6dcd0d22f9cdc5cd059d8587470

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Citations in the corpus

Mechanisms of stem cell self-renewal. (2009, background): “The premature aging of Klotho mutant mice has also been associated with increased Wnt signaling, and serum Klotho levels decline with age (Liu et al. 2007).”
Satellite cells and the muscle stem cell niche. (2013, background): “This possibility is supported by a recent finding that a Wnt binding protein, Klotho, is a circulating hormone and can affect tissue aging (281, 313).”
Klotho is a substrate for a-, - and ?-secretase (2009, background): “One function of the secreted Kl is to antagonize wnt signaling [19], another the activation of the calcium channel TRPV5 [20].”
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth (2008, background): “Interestingly, two recent studies have shown that increased Wnt signaling is associated with accelerated aging, suggesting that an attenuation of Wnt signaling might underlie CR and be beneficial not only for treating cancer but for more broadly attenuating diseases of aging [23,24].”
Programming the magnitude and persistence of antibody responses with innate immunity (2011, neutral): “vector RIG 0 2 4 6 vector KLm (1-1012) KLs (1-549) KLsss (34-549)”
Stems cells and the pathways to aging and cancer. (2008, background): “Activated Wnt signaling also appears to suppress stem/progenitor cell numbers in Klotho-deficient mice (Liu et al., 2007), which develop degenerative phenotypes linked to impaired vitamin-D homeostasis.”
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis (2009, background): “This possibility derives from the mechanistic analysis of the accelerated aging phenotype of klotho-deficient mice, a mutant mouse manifesting augmented Wnt signaling (Liu et al., 2007).”
Four faces of cellular senescence (2011, neutral): “, 2006), and dampens WNT signaling (Liu et al., 2007); the unopposed WNT signaling in Klotho-deficient mice is associated with the premature senescence of progenitor cells in several tissues.”
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation (2008, background): “Recently, inappropriate Wnt signalling was implicated in ageing through the senescence pathwa”
Aging, Cellular Senescence, and Cancer (2012, background): “Chronic WNT signaling can drive both differentiated and stem cells into senescence (101) (Figure 3).”
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer (2009, background): “Indeed, hyperactivation of the Wnt/β-catenin pathway is thought to induce premature senescence of stem cells and age-related loss of stem cell functio”
Senescence-messaging secretome: SMS-ing cellular stress (2009, background): “shows the opposite in both human and murine fibroblast cells: WNT3A caused these cells to enter senescence prematurel”