How stem cells age and why this makes us grow old

By N. Sharpless, R. DePinho. Nature reviews. Molecular cell biology, 2007

866 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/8d6c48cc1cb14345878e88f3cb5106681f4277bd

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Citations in the corpus

Molecular Interplay of the Non-coding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a (2010, neutral): “…and Pol II with RNA ChIP (Figure 1E), we detected that the ANRIL transcript initiates at start sites upstream of the INK4a and ARF genes on the opposing strand, preceding previously reported start sites by several hundred bases (Pasmant et al., 2007; Sharpless and DePinho, 2007; Yu et al., 2008).”
The DNA Damage Response: Making it safe to play with knives (2010, background): “Deficiency of p53, which also regulates cellular senescence, was shown to rescuemany of the progeroid features displayed in mTR-deficient mice due to defects of HSC and stem cells from the intestinal crypt and testis (Sharpless and DePinho, 2007).”
Child health, developmental plasticity, and epigenetic programming. (2011, background): “The variation in the life span of a species seems to be more strongly affected by the accumulation of molecular errors over time that compromise adult stem cell function than by specific genetic programs (332, 333).”
Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “Moreover, it has been suggested that the development and progression of these diseases could be ascribed to the decline of the regenerative functions of stem cells with advancing age (288).”
Hmga2 promotes neural stem cell self-renewal in young, but not old, mice by reducing p16Ink4a and p19Arf expression (2008, background): “In addition to contributing to the decline in stem cell function with age, p16 Ink4a , and perhaps p19 Arf , may also contribute to diseases of aging (Sharpless and DePinho, 2007).”
The hallmarks of aging. (2013, background): “Telomere shortening is also an important cause of stem cell decline with aging in multiple tissues (Flores et al., 2005; Sharpless and DePinho, 2007).”
Mechanisms of stem cell self-renewal. (2009, background): “DNA repair mechanisms are critical for maintaining genomic integrity in all cells, but they are particularly important in stem cells (Sharpless & DePinho 2007).”
Linking functional decline of telomeres, mitochondria and stem cells during ageing (2010, neutral): “This continuous self-renewal capacity is maintained by reservoirs of somatic tissue stem cell”