Hematopoietic stem cell quiescence maintained by p21cip1/waf1.

By T. Cheng, N. Rodrigues, Hongmei Shen, Yong-Guang Yang, D. Dombkowski, M. Sykes, D. Scadden. Science, 2000

1,390 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/1c850beb08be122cbc68fcc885afaf0f386f52c8

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In Genetics

1. S. Morrison
2. A. Trumpp
3. Anne Wilson
4. Fred H. Gage
5. P. Frenette
6. N. Sharpless
7. M. Clarke
8. G. Oser

In Molecular Biology

1. S. Morrison
2. Hans Clevers
3. R. Nusse
4. M. Clarke
5. N. Sharpless
6. Irving L. Weissman
7. Fred H. Gage
8. R. DePinho

In Oncology

1. S. Morrison
2. Zena Werb
3. M. Clarke
4. Irving L. Weissman
5. Dalong Qian
6. Y. Shimono
7. N. Lobo
8. C. López‐Otín

Citations in the corpus

• Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation (2003, background): “, and several genes that have not been previously identified as being regulated by Bmi-1 , such as the cyclin-dependent kinase inhibitor gene p21 , which regulates haematopoietic stem cell self-renewa”
• Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells. (2002, background): “These results are of significance since transplantation of stem cells from the bone marrow of p21 KO mice required five consecutive serial transplantations in order to fully reveal defects in stem cell self-renewal and repopulation potential [35], while CXCR4 null serial transplantations revealed si”
• Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. (2010, background): “when forced to proliferate (Cheng et al., 2000; Kippin et al., 2005; Ruzankina et al., 2007), and quiescence may function as a protective mechanism that counteracts stem cell exhaustion.”
• Arteriolar niches maintain haematopoietic stem cell quiescence (2013, positive): “Deletion `of genes involved in maintaining cell cycle quiescence has taught that unchecked HSC proliferation often leads to stem cell exhaustion 5–8 .”
• Cellular senescence in cancer and aging. (2007, positive): “A note of caution is warranted due to the fact that stem cell quiescence is also important to provide long-term regeneration potential, as it has been demonstrated for the cell cycle inhibitor p21Cip1 (Cheng et al., 2000).”
• The hallmarks of aging. (2013, background): “A similar situation is encountered in p21 null mice, which present premature exhaustion of HSCs and neural stem cells (Cheng et al., 2000; Kippin et al., 2005).”
• Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size (2005, background): “scribed in our previous publication (38).”