Cell intrinsic alterations underlie hematopoietic stem cell aging.

By Derrick J. Rossi, David Bryder, Jacob M. Zahn, H. Ahlenius, Rebecca J. Sonu, A. Wagers, Irving L. Weissman. Proceedings of the National Academy of Sciences of the United States of America, 2005

1,168 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/70113aaafbaac74aff4e36f50011dd4a0fcd96ec

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Citations in the corpus

Mechanisms of stem cell self-renewal. (2009, background): “Aging HSCs also exhibit increased myelopoiesis and decreased lymphopoiesis (Rossi et al. 2005) as well as decreased capacity to home to the bone marrow upon intravenous injection (Liang et al. 2005, Morrison et al. 1996b).”
Causes, consequences, and reversal of immune system aging. (2013, neutral): “This shift has been correlated with increased expression of myeloid lineage genes and downregulation of those specifying a lymphoid lineage fate (11, 17).”
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age (2011, background): “Notably, the results from our functional analysis and gene expression profiling of young and elderly human HSC significantly parallel the data we and others have generated on young and elderly mouse HSC (2, 6, 36).”
Stem cells, ageing and the quest for immortality (2006, background): “Recently, direct molecular analysis of purified HS cells revealed differences in gene expression between cells from young and old mic”
Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “Several changes in gene expression of old versus young HSCs have been described, including increased expression of leukemia-associated genes and decreased expression of genes contributing to DNA damage repair, genomic integrity, and chromatin remodeling (Rossi et al., 2005; Nijnik et al., 2007).”
DNA Methylation in Cancer and Aging. (2016, background): “Interestingly, several studies have already established that hematopoietic stem cells from bothmouse andman actually undergo a natural aging process whereby they increase in number while their lymphoid differentiation capacity is diminished, leading to a myeloid-dominant phenotype (34).”
Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGFβ1 (2010, positive): “Our lab and others have shown that aging mouse HSCs show a decline in long-term reconstituting potential (Chambers et al., 2007; Rossi et al., 2007) and a deficit in lymphopoiesis (Sudo et al., 2000; Rossi et al., 2005).”
How stem cells age and why this makes us grow old (2007, background): “Additionally, as stem cells appear to be less metabolically active in their quiescent state, they may be subjected to lower levels of DNA-damage-inducing metabolic side products such as reactive oxygen species (ROS”
Long-term propagation of distinct hematopoietic differentiation programs in vivo. (2007, background): “Several studies suggest that cells with a differentiation characteristics may increase as mice age (Sudo et al., 2000; Kim et al., 2003; Rossi et al., 2005; Liang et al., 2005).”
Stems cells and the pathways to aging and cancer. (2008, background): “Intriguingly, Bmi-1-mediated suppression of the p16Ink4a-p19Arf locus is dependent upon the presence of Ezh2 (Bracken et al., 2007), suggesting a mechanism through which reduced expression of Ezh2 in aged HSCs (Rossi et al., 2005) may lead to induction of p16Ink4a (Janzen et al., 2006).”
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal (2014, background): “…have established that, with age, phenotypically defined mouse and human HSCs increase in number, whereas lymphoid cell production is diminished, leading to a myeloid-dominant hematopoietic system (Chambers et al., 2007b; de Haan and Van Zant, 1999; Morrison et al., 1996; Rossi et al., 2005).”
Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation (2007, background): “Many of the observed expression changes are corroborated by a recent study of HSC aging [4].”