The plasticity of aging: insights from long-lived mutants.

By C. Kenyon. Cell, 2005

1,368 citations recorded by the source corpus.

Subfields: Aging, Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/4173fa3729045ba840d618b2aa0b1f0c98560ae6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. C. Kenyon
2. V. Longo
3. Ergun Sahin
4. R. DePinho
5. Brian K. Kennedy
6. R. Ricklefs
7. A. Brunet
8. Johan Auwerx

In Endocrine and Autonomic Systems

1. G. Lithgow
2. Rute Martins
3. W. Link
4. Luigi Fontana
5. R. DePinho
6. Ergun Sahin
7. V. Longo
8. T. Blackwell

In Physiology

1. Johan Auwerx
2. R. DePinho
3. Ergun Sahin
4. V. Longo
5. C. Cantó
6. R. Houtkooper
7. Brian K. Kennedy
8. G. Lithgow

Citations in the corpus

• Sirtuins in aging and age-related disease. (2006, background): “Notably, reduced activity of orthologs of these kinases and/or of the pathways in which they function lead to life-span extension in worms, flies, and mammals (Kenyon, 2005; Longo and Finch, 2003).”
• Stems cells and the pathways to aging and cancer. (2008, background): “These provocative findings suggest that stem cell numbers, aging, and diseases of stem cell origin may be modulated by pathways believed to be involved in mediating the antiaging effects of CR across species, such as the insulin-like growth factor (Igf1) pathway (Kenyon, 2005) or the Sir2 family of ”
• Insulin Action in Brain Regulates Systemic Metabolism and Brain Function (2014, background): “Several other alterations in the insulin/ IGF-1 pathway, such as overexpression of FoxO1 and inactivation of Akt, support the initial observation that reduced insulin/IGF-1 signaling in eukaryotes prolongs life span (115,116).”
• Linking functional decline of telomeres, mitochondria and stem cells during ageing (2010, positive): “Further complicating matters, the pace of mammalian ageing is influenced by external factors such as dietary intake, intrinsic stresses such as reactive oxygen species (ROS) and telomere erosion, and germline variation in genetic elements governing DNA repair, among other processe”
• p38 MAPK Regulates Expression of Immune Response Genes and Contributes to Longevity in C. elegans (2006, background): “aeruginosa infection, despite its well-known role in acute stress responses [7].”
• FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis During Aging (2010, background): “…in the mouse, the nematode Caenorhabditis elegans, and the fruitfly Drosophila melanogaster have expanded our understanding of the evolutionarily conserved signaling pathways regulating aging, with the identification of several mutants that have prolonged or shortened life spans (Kenyon, 2005).”
• Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans (2007, background): “elegans through the FOXO-transcription factor DAF-16 (Kenyon et al ., 1993; Tatar et al ., 2003; Kenyon, 2005).”
• Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. (2008, background): “1, PHA-4, DAF-16, and SKN-1 or their orthologs have all been shown to influence aspects of metabolism, and thereby presumably may affect the rates of damage that leads to aging (Accili and Arden, 2004; Bishop and Guarente, 2007; Kenyon, 2005; Panowski et al., 2007; van der Horst and Burgering, 2007)”
• A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. (2006, positive): “The entire PI3K-Akt-FOXO signaling cascade is conserved in nematodes and mammals (Kenyon, 2005; Van Der Heide et al., 2004).”