Rejuvenation of aged progenitor cells by exposure to a young systemic environment

By I. Conboy, M. Conboy, A. Wagers, Eric R. Girma, Irving L. Weissman, T. Rando. Nature, 2005

2,260 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/b127c9496a16bc7cabab463151a392dbac886ee7

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Citations in the corpus

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation (2012, positive): “…environment also significantly impacts the function of resident stem cells, with muscle and liver cells rejuvenated to a more youthful state when exposed to a young environment, and young cells adopting an aged phenotype in response to an aged environment (Conboy et al., 2005; Liu and Rando, 2011).”
The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018, background): “In fact, satellite cells from old muscles display a proliferative capacity similar to those derived from young muscles, if cultured in an appropriate medium enriched with plasma from young donors (59, 60), therefore casting some doubts on the fact that satellite cells from old muscle are actually de”
The hallmarks of aging. (2013, background): “Furthermore, parabiosis experiments have demonstrated that the decline in neural andmuscle stem cell function in old mice can be reversed by systemic factors from young mice (Conboy et al., 2005; Villeda et al., 2011).”
Designing materials to direct stem-cell fate (2009, background): “We think that the spatial and temporal control of these features would enhance their utility in tissue regeneration, improving tissue function and overcoming the adverse effects of disease or agein”
The aged niche disrupts muscle stem cell quiescence (2012, background): “The young systemic environment stimulates SC proliferation; the aged systemic environment inhibits SC proliferation 9,12 .”
Rejuvenation of regeneration in the aging central nervous system (2012, positive): “Using toxin-induced focal demyelination in the mouse spinal cord, together with heterochronic parabiosis (Conboy et al., 2005; Villeda et al., 2011), we tested whether exposure to a youthful systemic environment might improve remyelination by OPCs in the aged CNS.”
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion (2010, background): “However, as the epigenetic marks underlying these changes may be quite stable, it remains possible that ageassociated changes inHSC lineage potential may still be guided by instructive signals emanating from the aged systemic or microenvironments, as is the case with other stem cell systems (20, 21)”
Mechanisms of stem cell self-renewal. (2009, background): “Parabiosis of old and young mice or exposure of old satellite cells to young serum increases Notch ligand expression, muscle satellite cell proliferation, and muscle regenerative capacity, thereby demonstrating that local cues are regulated by circulating systemic factors (Conboy et al. 2005).”
The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity (2011, positive): “These systems have offered the simplicity of studying tissue-specific expression in organisms in which single-gene mutations can affect longevity, and have been extended to mammalian model systems (Bluher et al., 2003; Conboy et al., 2005; Taguchi et al., 2007).”
Remyelination in the CNS: from biology to therapy (2008, background): “Intriguing experiments on skeletal muscle regeneration using the technique of heterochronic parabiosis provide clear proof-of-principle that poor regeneration in old animals can be rejuvenate”