Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

By V. Janzen, R. Forkert, H. Fleming, Yoriko Saito, Michael T. Waring, D. Dombkowski, T. Cheng, R. DePinho, N. Sharpless, D. Scadden. Nature, 2006

1,103 citations recorded by the source corpus.

Subfields: Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/163b0acc80fdaf77bea15ecc451123236bf3c7e0

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In Molecular Biology

1. J. Campisi
2. K. Helin
3. Jesús Gil
4. S. Baylin
5. Manuel Serrano
6. Peter A. Jones
7. S. Morrison
8. M. Blasco

In Surgery

1. William Y. Kim
2. Manuel Serrano
3. Guido Kroemer
4. N. Sharpless
5. Navdeep S. Chandel

Citations in the corpus

• Ankyrin repeat: a unique motif mediating protein-protein interactions. (2006, background): “As for gankyrin, its physiological partners include CDK4 ( 56 , 58), Rb (65), S6 ATPase of the 26S proteasome (61), MAGE-A4 antigen (66), and HDM2 (67) (Figure 5c).”
• The regulation of INK4/ARF in cancer and aging. (2006, positive): “…INK4a -deficient and overexpressing mice to study self-renewal in three distinct tissues (HSCs, neural stem cells [NSCs], and pancreatic islets) has suggested that p16 INK4a expression is one cause of aging in these tissues (Janzen et al., 2006; Krishnamurthy et al., 2006; Molofsky et al., 2006).”
• DNA damage response and cellular senescence in tissues of aging mice (2009, background): “…2004), while a p21 knock-out rescued at least some accelerated aging phenotypes in telomerase (mTERC) knockout mice (Choudhury et al., 2007), and p16 knock-out rescued various mice stem cell systems from age-related decline (Janzen et al., 2006; Krishnamurthy et al., 2006; Molofsky et al., 2006).”
• Cellular senescence and its effector programs (2014, background): “But does senescence play a causative role in aging? A series of studies in 2006 touched on this important question (Janzen et al. 2006; Krishnamurthy et al. 2006; Molofsky et al. 2006).”
• The epigenomics of cancer. (2007, background): “Recent studies of knockout mice have revealed that germline loss of this gene increases stem cell life span (Janzen et al., 2006; Krishnamurthy et al., 2006; Molofsky et al., 2006), consistent with a proposed role in tumorigenesis for facilitating early abnormal clonal expansion of cells at risk…”
• A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. (2007, result): “This altered repopulating activity and shift in differentiation pattern in the ROS cell transplanted group is comparable to the phenomena seen in aged mice which have been reported to contain decreased percell repopulating activity and myeloid skewing of differentiation.(27) For personal use only.”
• The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. (2007, background): “Recently, Ink4a and Arf have been shown to accumulate in stem cells of old mice; however, the levels of Bmi1 are unchanged (Janzen et al. 2006; Krishnamurthy et al. 2006; Molofsky et al. 2006).”
• The hallmarks of aging. (2013, background): “Consequences of the exhaustion of hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs), satellite cells, and intestinal epithelial stem cells (IESCs) are exemplified.”
• Epigenetic Determinants of Cancer. (2016, background): “Furthermore, it also involves the expansion of stem cells, as observed in p16 mouse knockout models (Janzen et al. 2006).”
• Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. (2013, neutral): “(Janzen et al., 2006).”