Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

By D. Tuveson, A. Shaw, Nicholas A. Willis, D. Silver, E. Jackson, Sandy Chang, Kim L. Mercer, Rebecca Grochow, H. Hock, D. Crowley and 9 more. Cancer Cell, 2004

850 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/2e2ff633df9101a8d1cfb8b293fa656fd135b082

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Citations in the corpus

Senescence in tumours: evidence from mice and humans (2010, background): “However, other investigations have not found evidence for senescence in Kras G12D -driven lung lesion”
The signals and pathways activating cellular senescence. (2005, background): “In a recently described mouse tumor model carrying a single mutated copy of K-Ras, no signs of senescence were observed (Tuveson et al., 2004).”
Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer (2016, background): “…Cre (Ad5-CMV-Cre) to the lungs of animals harboring conditional KrasLSL-G12D/+; p53loxP/loxP (KP) alleles results in higher grade, metastatic tumors that progress rapidly and cause death within 12–16 weeks (DuPage et al., 2009; Jackson et al., 2001; Jonkers et al., 2001; Tuveson et al., 2004).”
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. (2004, neutral): “This effect was repro-binase (Tuveson et al., 2004).”
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. (2005, background): “Consistent with this view, mutational activa- v tion of RAS without overexpression stimulates cell pro- b liferation and transformation, not cellular senescence ( (Tuveson et al., 2004).”
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer (2005, methodology): “To induce expression of oncogenic K-ras within the OSE, we used the first injection technique to administer AdCre to the bursal cavity of lox P-Stop- lox P- K-ras G12D/+ ( LSL-K-ras G12D/+ ) mic”
The essence of senescence. (2010, background): “Subsequently, several groups reported that RAS and mutant RAF proteins act mitogenically or, conversely, drive cells into senescence as a function of increasing expression levels (Woods et al. 1997; Guerra et al. 2003; Deng et al. 2004; Tuveson et al. 2004; Sarkisian et al. 2007; Chen et al. 2009).”
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals (2010, background): “Conversely, KrasG12D, but not loss of NF2, led to activation of MAP kinase (Erk1/2) (Figure 6A; Figure S3D).”