J. Blenis

Molecular Biology · 2000–2018

A researcher in the Science corpus: 23 papers; trusts 39 researchers and is trusted by 52 researchers here, as inferred from the citation graph.

Subfields

• Molecular Biology — 226 citations into it; #495 of 17,773 by trust here, #525 by citations
• Cell Biology — 31 citations into it
• Physiology — 25 citations into it; #66 of 2,276 by trust here, #136 by citations
• Oncology — 19 citations into it
• Cancer Research — 15 citations into it
• Genetics — 13 citations into it
• Pathology and Forensic Medicine — 12 citations into it; #321 of 414 by trust here, #66 by citations
• Cellular and Molecular Neuroscience — 11 citations into it

Whom J. Blenis trusts overall

Their strongest outbound trust, strongest first, inferred from their citations.

1. Philippe P Roux
2. D. Fingar
3. Lewis C. Cantley
4. B. Manning
5. J. Kyriakis
6. K. Inoki
7. A. Newton
8. Leon O. Murphy
9. Bryan A. Ballif
10. A. Gingras

Who trusts J. Blenis overall

1. David M. Sabatini
2. A. Budanov
3. L. Bar-Peled
4. M. Laplante
5. B. Manning
6. Young Chul Kim
7. Jingxiang Huang
8. R. Anjum
9. K. Inoki
10. R. Roskoski

Papers from J. Blenis's perspective

Ordered by how strongly the researchers J. Blenis trusts endorse each paper. Same corpus, a different order for every researcher.

1. TSC2 mediates cellular energy response to control cell growth and survival. (Cell)
2. TOR signaling in growth and metabolism. (Cell)
3. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. (Genes & Development)
4. The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif* (Journal of Biological Chemistry)
5. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. (Molecules and Cells)
6. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. (Cancer Cell)
7. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. (Cell)
8. Inaugural Article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
9. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer (Nature Medicine)
10. Mammalian TOR: A Homeostatic ATP Sensor (Science)

Their papers

• Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. (2004) — 797 citations
• Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. (2002) — 1,595 citations
• Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. (2002) — 1,118 citations
• Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. (2003) — 1,260 citations
• An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice (2001) — 620 citations
• Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression (2004) — 1,302 citations
• Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling (2002) — 850 citations
• Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation (2008) — 856 citations
• Quantitative Phosphoproteomic Analysis Identifies the Adaptor Protein Grb10 as an mTORC1 Substrate that Negatively Regulates Insulin Signaling (2011) — 789 citations
• mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E (2004) — 903 citations
• Molecular interpretation of ERK signal duration by immediate early gene products (2002) — 1,006 citations
• Molecular mechanisms of mTOR-mediated translational control (2009) — 2,604 citations
• mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. (2005) — 596 citations
• Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance (2005) — 598 citations
• RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation* (2007) — 763 citations
• ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions (2004) — 2,565 citations
• The RSK family of kinases: emerging roles in cellular signalling (2008) — 796 citations
• MAPK signal specificity: the right place at the right time. (2006) — 740 citations
• Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric-flow field-flow fractionation (2018) — 1,416 citations
• Rapamycin: one drug, many effects (2014) — 1,157 citations