mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.

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TOR signaling in growth and metabolism. (2006, background): “Interestingly, Holz et al. (2005) have shown that the eukaryotic translation initiation factor eIF3 acts as a scaffold for mTORC1 and S6K1. mTORC1 promotes cap-dependent translation initiation through phosphorylation of eIF4E binding proteins (4E-BPs).”
The gene encoding the splicing factor SF2/ASF is a proto-oncogene (2007, background): “Human RPS6KB1 encodes S6K1, a kinase that phosphorylates the small-subunit ribosomal protein S6 and regulates translatio”
Defining the role of mTOR in cancer. (2007, background): “The eIF3 complex facilitates mTORC1-dependent phosphorylation of S6K1 and 4E-BP1 by functioning as a scaffold that mediates the enzyme-substrate interactions (Holz et al., 2005).”
Molecular mechanisms of mTOR-mediated translational control (2009, background): “Growth factor-mediated phosphorylation of eIF4B can dramatically increase its association with eIF4”
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. (2012, unknown): “…Akt substrate of 40 kDa (PRAS40), and Deptor (Bhaskar and Hay, 2007; Foster and Fingar, 2010). mTORC1 phosphorylation of S6K and 4E-BP is the rate-limiting step in translation, which leads to translation initiation of mRNAs displaying a 50 cap structure (Ma and Blenis, 2009; Holz et al., 2005).”