Mammalian TOR: A Homeostatic ATP Sensor

By P. Dennis, A. Jaeschke, M. Saitoh, B. Fowler, S. Kozma, George Thomas. Science, 2001

976 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7965cfc34f50b550cc2fd2f8cb8ac8738e5d0fad

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Citations in the corpus

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling (2002, background): “To examine a role for mTOR in the function of TSC1–TSC2, we tested the rapamycin-resistant mutants, S6K-dC104 and S6K-dN”
Lysosomal Physiology (2015, background): “Under certain conditions, mTOR’s ATP sensitivity is within the millimolar range (116), making the kinase a feasible ATP sensor for the channel.”
Regulation and role of autophagy in mammalian cells. (2004, background): “…candi- date as a “gate keeper” of the autophagic pathway, because it is a sensor for amino acids and ATP and because it can integrate hormonal stimuli via the class I PI-3K/PKB pathway (Dennis et al., 2001; Marygold & Leevers, 2002; Rohde, Heitman, & Cardenas, 2001) which also control autophagy.”
TOR signalling in bugs, brain and brawn (2003, background): “Furthermore, mTOR seems to respond positively to phosphatidic acid and ATP, both of which are produced in response to growth factor”
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. (2003, background): “Because it was shown that the intracellular levels of ATP (Dennis et al. 2001) modulate mTOR activity, it is possible that a prospective alternate pathway may be related to the ability of Akt to increase intracellular ATP (Gottlob et al. 2001).”
Dysregulation of the TSC-mTOR pathway in human disease (2004, background): “Cellular ATP depletion markedly inhibits phosphorylation of S6K and 4EBP1 without affecting PI3K activation or intracellular amino acid level”
The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis (2016, neutral): “Mammalian target of rapamycin (mTOR) has been suggested as another type of ATP sensor because its Michaelis constant (KM) value for ATP falls within the range of physiological cellular concentration and its kinase activity changes in direct proportion to the cellular ATP concentration (Chen et al., ”
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 (2007, background): “mTOR, a member of the phosphatidyl-inositol kinase-related protein kinase family, is an important regulator of the growth of mammals in response to the availability of nutrients, and is a key mediator of insulin, insulin-like growth factor 1 and other growth-factor signals to the cell growth machine”
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. (2002, background): “…suggest that the mitochondrial metabactivity and that raptor overexpression can circumventolism of nutrients is necessary to activate the pathway the normal nutrient-regulated mechanism(s) that control(Dennis et al., 2001; Xu et al., 2001; D.D.S., D.-H.K., and the strength of the interaction.”
Molecular mechanisms of mTOR-mediated translational control (2009, neutral): “Because energy depletion severely decreases mTORC1 activit”