Molecular mechanisms of mTOR-mediated translational control

By X. Ma, J. Blenis. Nature reviews. Molecular cell biology, 2009

2,604 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c7ec3beb55cf50c9c7693a8a14784ea09935154a

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In Molecular Biology

1. David M. Sabatini
2. M. Laplante
3. L. Bar-Peled
4. M. V. Vander Heiden
5. Roberto Zoncu
6. B. Manning
7. Timothy R. Peterson
8. Shomit Sengupta

Citations in the corpus

• Regulation of Immune Responses by mTOR (2011, background): “S6K1 plays a critical role in promoting translation of mRNA and is activated by mTORC1, whereas 4E-BP1 is an inhibitor of eIF-4E, a cap-binding protein, and its phosphorylation by mTOR leads to its inactivation (36).”
• Regulation of mTORC1 by amino acids (2014, positive): “To stimulate cell growth, mTORC1 relies on its downstream effectors to coordinately promote anabolic programs such as mRNA translation (10) and repress catabolic programs such as autophagy (11), thereby avoiding a futile cycle of uncoordinated synthesis and degradation.”
• An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1 (2012, neutral): “When active, mTORC1 stimulates anabolic processes, such as translation, transcription, lipid biosynthesis, and ribosome biogenesis and inhibits catabolic processes, such as autophagy (reviewed in Howell andManning, 2011; Ma and Blenis, 2009; Zoncu et al., 2011b).”
• Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes (2017, background): “Lastly, mTORC1 inhibition suppresses mRNA translation (32), but the protein synthesis inhibitor Abu-Remaileh et al.”
• Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress (2010, background): “…to mTORC1-mediated phosphorylation promotes mRNA translation through several substrates, such as S6K1 aly/REF-like target (SKAR), programmed cell death 4 (PDCD4), eukaryotic elongation factor 2 kinase (eEF-2K), eukaryotic initiation factor 4B (eIF4B), and ribosomal protein S6 (Ma and Blenis, 2009).”
• Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. (2012, neutral): “…Akt substrate of 40 kDa (PRAS40), and Deptor (Bhaskar and Hay, 2007; Foster and Fingar, 2010). mTORC1 phosphorylation of S6K and 4E-BP is the rate-limiting step in translation, which leads to translation initiation of mRNAs displaying a 50 cap structure (Ma and Blenis, 2009; Holz et al., 2005).”
• The lipid kinase PI5P4Kβ is an intracellular GTP sensor for metabolism and tumorigenesis (2016, neutral): “188 Molecular Cell 61, 187–198, January 21, 2016 a2016 Elsevier Inc amount of GTP is required in rapidly dividing cells, such as tumor cells, and tissues producing serum proteins, such as the liver, pancreas, and adipose tissue (Caro and Palade, 1964; Havel, 2002; Ma and Blenis, 2009; Miller et al.,”
• A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1 (2013, neutral): “Mass spectrometric analyses HEK-293T cells stably expressing FLAG-tagged Metap2, RagB, Mios, DEPDC5, WDR24, or Nprl2 were chemically crosslinked with DSP prior to cell lysis with Triton lysis buffer as described in (2).”
• PTEN Deletion Enhances the Regenerative Ability of Adult Corticospinal Neurons (2010, methodology): “We used Cre-expressing adeno-associated virus (AAV-Cre) to delete Pten , a negative regulator of mTO”
• With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging (2010, positive): “The mammalian orthologs of PHA-4, the Foxa transcription factors Foxa1, Foxa2, and Foxa3, also play important roles during development, and act later in life to regulate glucagon production and glucose homeostasis in response to fasting (Mair and Dillin, 2008).”
• TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO (2012, background): “The TOR (target of rapamycin) kinase integrates nutrient and anabolic signals to promote growth (Ma and Blenis, 2009; Wullschleger et al., 2006; Zoncu et al., 2011).”
• mTOR signaling at a glance (2009, background): “…and elongation, and the translation of ribosomal proteins through regulation of the activity of many proteins, such as S6K1 aly/REF-like target (SKAR), programmed cell death 4 (PDCD4), eukaryotic elongation factor 2 kinase (eEF2K) and ribosomal protein S6 (reviewed by Ma and Blenis, 2009).”